Version 5.4
Homo sapiens Gene: CTNNAL1
Summary
InnateDB Gene IDBG-80038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNAL1
Gene Name catenin (cadherin-associated protein), alpha-like 1
Synonyms ACRP; alpha-CATU; CLLP
Species Homo sapiens
Ensembl Gene ENSG00000119326
Encoded Proteins
IDBP-80040
catenin (cadherin-associated protein), alpha-like 1
IDBP-80044
catenin (cadherin-associated protein), alpha-like 1
IDBP-80046
catenin (cadherin-associated protein), alpha-like 1
IDBP-80048
catenin (cadherin-associated protein), alpha-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17952117
CTNNAL1 is an alpha-catenin-related protein that shares structural similarities with cytoskeleton linker proteins that augments NF-kappaB activity, promotes cell migration and increases resistance to apoptosis.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108942569-109013529
Strand Reverse strand
Band q31.3
Transcripts
ENST00000325551 ENSP00000320434
ENST00000374595 ENSP00000363723
ENST00000374594 ENSP00000363722
ENST00000374593 ENSP00000363721
ENST00000488130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 11 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
GO:0007266 Rho protein signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038816
View Gene Order
ENSBTAG00000004997
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5JTQ6
UniProt Splice Variant
Entrez Gene 8727
UniGene
RefSeq NM_001286974 NM_003798 XM_005252291
HUGO HGNC:2512
OMIM 604785
CCDS CCDS6775 CCDS69638
HPRD 09210
IMGT
EMBL AL354797
GenPept
RNA Seq Atlas 8727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca