Homo sapiens Gene: STUB1
Summary
InnateDB Gene IDBG-8030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STUB1
Gene Name STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Synonyms CHIP; HSPABP2; NY-CO-7; SCAR16; SDCCAG7; UBOX1;
Species Homo sapiens
Ensembl Gene ENSG00000103266
Encoded Proteins
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
STUB1 facilitates the formation of a TLR signalling complex by recruiting, ubiquitinating, and activating Src and PRKCZ. Knockdown of Stub1 in mice inhibits Tlr4- and Tlr9-signalling pathways. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Stub1 facilitates the formation of a TLR signalling complex by recruiting, ubiquitinating, and activating Src and Prkcz. Knockdown of Stub1 inhibits Tlr4- and Tlr9-signalling pathways.
Entrez Gene
Summary STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009]
This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:680224-682870
Strand Forward strand
Band p13.3
Transcripts
ENST00000219548 ENSP00000219548
ENST00000567790
ENST00000566408 ENSP00000457583
ENST00000569248
ENST00000564370 ENSP00000456875
ENST00000566181
ENST00000565677 ENSP00000457228
ENST00000563505
ENST00000564316 ENSP00000457090
ENST00000567173 ENSP00000456591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 331 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 331 [view]
Protein-Protein 328 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0030544 Hsp70 protein binding
GO:0030674 protein binding, bridging
GO:0030911 TPR domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0042803 protein homodimerization activity
GO:0046332 SMAD binding
GO:0051787 misfolded protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 misfolded or incompletely synthesized protein catabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016567 protein ubiquitination
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
GO:0031943 regulation of glucocorticoid metabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051604 protein maturation
GO:0051865 protein autoubiquitination
GO:0070534 protein K63-linked ubiquitination
GO:0071218 cellular response to misfolded protein
GO:0090035 positive regulation of chaperone-mediated protein complex assembly
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031371 ubiquitin conjugating enzyme complex
GO:0042405 nuclear inclusion body
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by ERBB2 pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Alpha-synuclein signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592081
RefSeq NM_001293197 NM_005861
HUGO
OMIM
CCDS CCDS10419
HPRD 06232
IMGT
EMBL
GenPept
RNA Seq Atlas