Homo sapiens Gene: TXN
Summary
InnateDB Gene IDBG-80361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXN
Gene Name thioredoxin
Synonyms TRDX; TRX; TRX1;
Species Homo sapiens
Ensembl Gene ENSG00000136810
Encoded Proteins
thioredoxin
thioredoxin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:110243811-110256640
Strand Reverse strand
Band q31.3
Transcripts
ENST00000374517 ENSP00000363641
ENST00000374515 ENSP00000363639
ENST00000487892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015035 protein disulfide oxidoreductase activity
GO:0015037 peptide disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006662 glycerol ether metabolic process
GO:0006928 cellular component movement
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0009314 response to radiation
GO:0015949 nucleobase-containing small molecule interconversion
GO:0033158 regulation of protein import into nucleus, translocation
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043388 positive regulation of DNA binding
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045454 cell redox homeostasis
GO:0046826 negative regulation of protein export from nucleus
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Cellular responses to stress pathway
Innate Immune System pathway
Detoxification of Reactive Oxygen Species pathway
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Inflammasomes pathway
Metabolism of nucleotides pathway
Cellular Senescence pathway
The NLRP3 inflammasome pathway
Metabolism pathway
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID BIOCARTA
PID NCI
TNF receptor signaling pathway
Signaling events mediated by PTP1B
p38 MAPK signaling pathway
Cross-References
SwissProt P10599
TrEMBL
UniProt Splice Variant
Entrez Gene 7295
UniGene Hs.615540
RefSeq NM_001244938 NM_003329
HUGO HGNC:12435
OMIM 187700
CCDS CCDS59139 CCDS35103
HPRD 01761
IMGT
EMBL AF065241 AF276919 AF313911 AF548001 AK289508 AL158158 AY004872 BC003377 BC054866 CH471105 CR407665 J04026 X54539 X54540 X54541 X77584
GenPept AAA74596 AAC17430 AAF86466 AAF87085 AAG34699 AAH03377 AAH54866 AAN33187 BAF82197 CAA38410 CAA54687 CAG28593 CAI14066 CAI14067 EAW59059 EAW59060
RNA Seq Atlas 7295