Version 5.4
Homo sapiens Gene: IGFBP2
Summary
InnateDB Gene IDBG-80727.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP2
Gene Name insulin-like growth factor binding protein 2, 36kDa
Synonyms IBP2; IGF-BP53
Species Homo sapiens
Ensembl Gene ENSG00000115457
Encoded Proteins
IDBP-80729
insulin-like growth factor binding protein 2, 36kDa
IDBP-388834
insulin-like growth factor binding protein 2, 36kDa
IDBP-388835
insulin-like growth factor binding protein 2, 36kDa
IDBP-388836
insulin-like growth factor binding protein 2, 36kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:216632828-216664436
Strand Forward strand
Band q35
Transcripts
ENST00000233809 ENSP00000233809
ENST00000434997 ENSP00000401698
ENST00000456764 ENSP00000389646
ENST00000436812 ENSP00000400308
ENST00000490362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007568 aging
GO:0007584 response to nutrient
GO:0009612 response to mechanical stimulus
GO:0010226 response to lithium ion
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032870 cellular response to hormone stimulus
GO:0042104 positive regulation of activated T cell proliferation
GO:0042493 response to drug
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043627 response to estrogen
GO:0044267 cellular protein metabolic process
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039323
View Gene Order
ENSBTAG00000005596
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL H7C1H0
UniProt Splice Variant
Entrez Gene 3485
UniGene Hs.438102
RefSeq NM_000597
HUGO HGNC:5471
OMIM 146731
CCDS CCDS42815
HPRD 00898
IMGT
EMBL AC007563 AC073321
GenPept
RNA Seq Atlas 102723473 3485

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca