Version 5.4
Homo sapiens Gene: HLA-DRB5
Summary
InnateDB Gene IDBG-80827.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DRB5
Gene Name major histocompatibility complex, class II, DR beta 5
Synonyms HLA-DRB
Species Homo sapiens
Ensembl Gene ENSG00000198502
Encoded Proteins
IDBP-80829
major histocompatibility complex, class II, DR beta 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32517343-32530287
Strand Reverse strand
Band p21.32
Transcripts
ENST00000374975 ENSP00000364114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042605 peptide antigen binding
Biological Process
GO:0006955 immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295 T cell costimulation
GO:0050852 T cell receptor signaling pathway
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0042613 MHC class II protein complex
GO:0070062 extracellular vesicular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_12596
Translocation of ZAP-70 to Immunological synapse pathway
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_25078
Interferon gamma signaling pathway
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12526
TCR signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04940
Type I diabetes mellitus pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05332
Graft-versus-host disease pathway
hsa05310
Asthma pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05145
Toxoplasmosis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q30154
TrEMBL A0A024F8S6 A1A424 Q06654 Q06663 Q2YHL2 Q30009 Q30138 Q30141 Q5TJ21 Q95385
UniProt Splice Variant
Entrez Gene 3127
UniGene
RefSeq NM_002125
HUGO HGNC:4953
OMIM 604776
CCDS CCDS4751
HPRD
IMGT
EMBL AB829537 AF122887 AJ271159 AJ427352 AJ854250 AK314834 AL713966 AM159646 AY141137 AY457037 AY604591 BC009234 FN430425 M16954 M16955 M17377 M20429 M30182 M35159 M81171 M81180 M91001 U31770 U59685 U66721 X64544 X64548 X87210 Y09342 Y13727 Z83201
GenPept AAA36276 AAA36277 AAA59715 AAA59791 AAA59818 AAA59822 AAA91838 AAA91847 AAB52229 AAB52232 AAB63983 AAD31766 AAH09234 AAN28924 AAR20446 AAV33684 BAG37353 BAO73172 CAA45842 CAA45846 CAA70524 CAA74055 CAB05668 CAB71144 CAD20460 CAI05916 CAI18079 CAJ43899 CAZ86696
RNA Seq Atlas 3127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca