Homo sapiens Gene: HLA-DRB5
InnateDB Gene IDBG-80827.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DRB5
Gene Name major histocompatibility complex, class II, DR beta 5
Synonyms HLA-DRB
Species Homo sapiens
Ensembl Gene ENSG00000198502
Encoded Proteins
major histocompatibility complex, class II, DR beta 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32517343-32530287
Strand Reverse strand
Band p21.32
ENST00000374975 ENSP00000364114
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042605 peptide antigen binding
Biological Process
GO:0006955 immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295 T cell costimulation
GO:0050852 T cell receptor signaling pathway
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0042613 MHC class II protein complex
GO:0070062 extracellular vesicular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
No orthologs found for this gene
MHC class II antigen presentation pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Interferon gamma signaling pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Hematopoietic cell lineage pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Type I diabetes mellitus pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Graft-versus-host disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Toxoplasmosis pathway
Phagosome pathway
SwissProt Q30154
TrEMBL A0A024F8S6 A1A424 Q06654 Q06663 Q2YHL2 Q30009 Q30138 Q30141 Q5TJ21 Q95385
UniProt Splice Variant
Entrez Gene 3127
RefSeq NM_002125
OMIM 604776
EMBL AB829537 AF122887 AJ271159 AJ427352 AJ854250 AK314834 AL713966 AM159646 AY141137 AY457037 AY604591 BC009234 FN430425 M16954 M16955 M17377 M20429 M30182 M35159 M81171 M81180 M91001 U31770 U59685 U66721 X64544 X64548 X87210 Y09342 Y13727 Z83201
GenPept AAA36276 AAA36277 AAA59715 AAA59791 AAA59818 AAA59822 AAA91838 AAA91847 AAB52229 AAB52232 AAB63983 AAD31766 AAH09234 AAN28924 AAR20446 AAV33684 BAG37353 BAO73172 CAA45842 CAA45846 CAA70524 CAA74055 CAB05668 CAB71144 CAD20460 CAI05916 CAI18079 CAJ43899 CAZ86696
RNA Seq Atlas 3127