|Homo sapiens Gene: CEBPB|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CCAAT/enhancer binding protein (C/EBP), beta|
|Synonyms||C/EBP-beta; IL6DBP; NF-IL6; TCF5;|
CCAAT/enhancer binding protein (C/EBP), beta
|Useful resources||Stemformatics EHFPI ImmGen|
CEBPB, one of the CEBP family members, is a crucial regulator of gene expression during innate immunity, inflammatory responses and adipogenesis. All of the individual CEBPB isoforms, LAP1, LAP2 and LIP, attenuate EGF-induced PTGS2 (COX-2) promoter activity.
CEBPB is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
CREB1 and CEBPB are involved in cytokine production in neutrophils in response to LPS and TNF.
|InnateDB Annotation from Orthologs|
[Mus musculus] Cebpb is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
[Mus musculus] LPS stimulation promotes the formation of CEBPB complexes on the Serpinb2 promoter to drive transcription.
[Mus musculus] Tnfaip3 is regulated by both Nf-κB and p38-dependent Cebpb in response to LPS in macrophages.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
|Genomic Location||Chromosome 20:50190734-50192689|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Cellular responses to stress pathway
Developmental Biology pathway
Cellular Senescence pathway
Transcriptional regulation of white adipocyte differentiation pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Validated nuclear estrogen receptor alpha network
C-MYB transcription factor network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
Signaling mediated by p38-alpha and p38-beta
IL3-mediated signaling events
FOXA1 transcription factor network
IL6-mediated signaling events
|UniProt Splice Variant|
|RefSeq||NM_001285878 NM_001285879 NM_005194|
|EMBL||AF289608 AK291536 AL161937 AY193834 BC005132 BC007538 BC021931 CH471077 KJ161450 KJ161451 KJ161452 KJ161453 KJ161454 KJ161455 KJ161456 KJ161457 KJ161458 KJ161459 KJ161460 KJ161461 KJ161462 KJ161463 KJ161464 KJ161465 KJ161466 KJ161470 KJ161471 KJ161472 KJ161473 KJ161474 KJ161475 KJ161476 KJ161477 KJ161478 KJ161479 KJ161480 KJ161481 X52560|
|GenPept||AAH05132 AAH07538 AAH21931 AAL55792 AAN86350 AHM26727 AHM26728 AHM26729 AHM26730 AHM26731 AHM26732 AHM26733 AHM26734 AHM26735 AHM26736 AHM26737 AHM26738 AHM26739 AHM26740 AHM26741 AHM26742 AHM26743 AHM26747 AHM26748 AHM26749 AHM26750 AHM26751 AHM26752 AHM26753 AHM26754 AHM26755 AHM26756 AHM26757 AHM26758 BAF84225 CAA36794 CAC14276 EAW75629|
|RNA Seq Atlas||1051|