Homo sapiens Gene: CEBPB
Summary
InnateDB Gene IDBG-80858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEBPB
Gene Name CCAAT/enhancer binding protein (C/EBP), beta
Synonyms C/EBP-beta; IL6DBP; NF-IL6; TCF5;
Species Homo sapiens
Ensembl Gene ENSG00000172216
Encoded Proteins
CCAAT/enhancer binding protein (C/EBP), beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CEBPB, one of the CEBP family members, is a crucial regulator of gene expression during innate immunity, inflammatory responses and adipogenesis. All of the individual CEBPB isoforms, LAP1, LAP2 and LIP, attenuate EGF-induced PTGS2 (COX-2) promoter activity.
CEBPB is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
CREB1 and CEBPB are involved in cytokine production in neutrophils in response to LPS and TNF.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cebpb is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
[Mus musculus] LPS stimulation promotes the formation of CEBPB complexes on the Serpinb2 promoter to drive transcription.
[Mus musculus] Tnfaip3 is regulated by both Nf-κB and p38-dependent Cebpb in response to LPS in macrophages.
Entrez Gene
Summary The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:50190734-50192689
Strand Forward strand
Band q13.13
Transcripts
ENST00000303004 ENSP00000305422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 169 [view]
Protein-Protein 104 [view]
Protein-DNA 63 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035259 glucocorticoid receptor binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001892 embryonic placenta development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0030182 neuron differentiation
GO:0032496 response to lipopolysaccharide
GO:0033598 mammary gland epithelial cell proliferation
GO:0034976 response to endoplasmic reticulum stress
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0045444 fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050873 brown fat cell differentiation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060850 regulation of transcription involved in cell fate commitment
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0000779 condensed chromosome, centromeric region
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
EGFR1 pathway
TCR pathway
IL4 pathway
IL6 pathway
RANKL pathway
Oncostatin_M pathway
REACTOME
Cellular responses to stress pathway
Developmental Biology pathway
Cellular Senescence pathway
Transcriptional regulation of white adipocyte differentiation pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
KEGG
INOH
PID BIOCARTA
Il 6 signaling pathway [Biocarta view]
PID NCI
Validated nuclear estrogen receptor alpha network
C-MYB transcription factor network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
Signaling mediated by p38-alpha and p38-beta
IL3-mediated signaling events
FOXA1 transcription factor network
IL6-mediated signaling events
IFN-gamma pathway
Cross-References
SwissProt P17676
TrEMBL Q9BSC0 W8SNV5
UniProt Splice Variant
Entrez Gene 1051
UniGene Hs.719041
RefSeq NM_001285878 NM_001285879 NM_005194
HUGO HGNC:1834
OMIM 189965
CCDS CCDS13429
HPRD
IMGT
EMBL AF289608 AK291536 AL161937 AY193834 BC005132 BC007538 BC021931 CH471077 KJ161450 KJ161451 KJ161452 KJ161453 KJ161454 KJ161455 KJ161456 KJ161457 KJ161458 KJ161459 KJ161460 KJ161461 KJ161462 KJ161463 KJ161464 KJ161465 KJ161466 KJ161470 KJ161471 KJ161472 KJ161473 KJ161474 KJ161475 KJ161476 KJ161477 KJ161478 KJ161479 KJ161480 KJ161481 X52560
GenPept AAH05132 AAH07538 AAH21931 AAL55792 AAN86350 AHM26727 AHM26728 AHM26729 AHM26730 AHM26731 AHM26732 AHM26733 AHM26734 AHM26735 AHM26736 AHM26737 AHM26738 AHM26739 AHM26740 AHM26741 AHM26742 AHM26743 AHM26747 AHM26748 AHM26749 AHM26750 AHM26751 AHM26752 AHM26753 AHM26754 AHM26755 AHM26756 AHM26757 AHM26758 BAF84225 CAA36794 CAC14276 EAW75629
RNA Seq Atlas 1051