Homo sapiens Gene: RAC1
Summary
InnateDB Gene IDBG-8115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAC1
Gene Name ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Synonyms p21-Rac1; Rac-1; TC-25;
Species Homo sapiens
Ensembl Gene ENSG00000136238
Encoded Proteins
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RAC1 cooperates with TLR2, MyD88, and PI3K in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cd81 inhibits Rac1/Stat1 activation and negatively regulates the defence mechanisms to Listeria monocytogenes infection.
Entrez Gene
Summary The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:6374523-6403977
Strand Forward strand
Band p22.1
Transcripts
ENST00000356142 ENSP00000348461
ENST00000348035 ENSP00000258737
ENST00000488373
ENST00000497741
ENST00000473564
ENST00000495499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 242 [view]
Protein-Protein 239 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017137 Rab GTPase binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030742 GTP-dependent protein binding
GO:0031996 thioesterase binding
GO:0051022 Rho GDP-dissociation inhibitor binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002093 auditory receptor cell morphogenesis
GO:0002551 mast cell chemotaxis
GO:0003382 epithelial cell morphogenesis
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006972 hyperosmotic response
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010592 positive regulation of lamellipodium assembly
GO:0015031 protein transport
GO:0016032 viral process
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021831 embryonic olfactory bulb interneuron precursor migration
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030168 platelet activation
GO:0030334 regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031529 ruffle organization
GO:0032707 negative regulation of interleukin-23 production
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 positive regulation of apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043652 engulfment of apoptotic cell
GO:0045087 innate immune response (InnateDB)
GO:0045216 cell-cell junction organization
GO:0045453 bone resorption
GO:0045740 positive regulation of DNA replication
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048532 anatomical structure arrangement
GO:0048813 dendrite morphogenesis
GO:0048870 cell motility
GO:0050690 regulation of defense response to virus by virus
GO:0051668 localization within membrane
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060263 regulation of respiratory burst
GO:0071526 semaphorin-plexin signaling pathway
GO:0071542 dopaminergic neuron differentiation
GO:0072659 protein localization to plasma membrane
GO:0090103 cochlea morphogenesis
GO:0097178 ruffle assembly
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0019897 extrinsic component of plasma membrane
GO:0030027 lamellipodium
GO:0031410 cytoplasmic vesicle
GO:0032587 ruffle membrane
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042470 melanosome
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
Wnt pathway
IL6 pathway
TWEAK pathway
REACTOME
PCP/CE pathway pathway
Sema4D in semaphorin signaling pathway
Regulation of actin dynamics for phagocytic cup formation pathway
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Signalling by NGF pathway
Nef and signal transduction pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Cell-Cell communication pathway
beta-catenin independent WNT signaling pathway
Semaphorin interactions pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
EPHB-mediated forward signaling pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Activation of Rac pathway
Signal Transduction pathway
GPCR downstream signaling pathway
CD28 co-stimulation pathway
CD28 dependent Vav1 pathway pathway
Sema3A PAK dependent Axon repulsion pathway
Netrin-1 signaling pathway
NRAGE signals death through JNK pathway
Adaptive Immune System pathway
Immune System pathway
Ephrin signaling pathway
GPVI-mediated activation cascade pathway
VEGFA-VEGFR2 Pathway pathway
DCC mediated attractive signaling pathway
Translocation of GLUT4 to the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
L1CAM interactions pathway
Signal transduction by L1 pathway
Factors involved in megakaryocyte development and platelet production pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-ephrin mediated repulsion of cells pathway
DSCAM interactions pathway
HIV Infection pathway
EPH-Ephrin signaling pathway
Signaling by Robo receptor pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Inactivation of Cdc42 and Rac pathway
Costimulation by the CD28 family pathway
Host Interactions of HIV factors pathway
Sema4D induced cell migration and growth-cone collapse pathway
Disease pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
Membrane Trafficking pathway
KEGG
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
Phagosome pathway
Wnt signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Adherens junction pathway
Toll-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pancreatic secretion pathway
Amyotrophic lateral sclerosis (ALS) pathway
Bacterial invasion of epithelial cells pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
Integrin signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
Y branching of actin filaments [Biocarta view]
Ucalpain and friends in cell spread [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Bcr signaling pathway [Biocarta view]
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
How does salmonella hijack a cell [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Ras signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Nephrin/Neph1 signaling in the kidney podocyte
Thromboxane A2 receptor signaling
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events
S1P1 pathway
Regulation of RAC1 activity
LPA receptor mediated events
Netrin-mediated signaling events
Integrins in angiogenesis
S1P2 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ErbB1 downstream signaling
Alpha9 beta1 integrin signaling events
Nectin adhesion pathway
a6b1 and a6b4 Integrin signaling
Signaling events mediated by focal adhesion kinase
Integrin-linked kinase signaling
EPHB forward signaling
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
Arf1 pathway
RAC1 signaling pathway
Endothelins
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Ephrin B reverse signaling
Signaling events mediated by PRL
CDC42 signaling events
S1P3 pathway
Syndecan-4-mediated signaling events
Regulation of p38-alpha and p38-beta
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
Arf6 downstream pathway
Noncanonical Wnt signaling pathway
EPHA2 forward signaling
Lissencephaly gene (LIS1) in neuronal migration and development
E-cadherin signaling in keratinocytes
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
IL6-mediated signaling events
N-cadherin signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Osteopontin-mediated events
p38 MAPK signaling pathway
Cross-References
SwissProt P63000
TrEMBL A4D2P0
UniProt Splice Variant
Entrez Gene 5879
UniGene Hs.702986
RefSeq NM_018890 NM_006908
HUGO HGNC:9801
OMIM 602048
CCDS CCDS5349 CCDS5348
HPRD 03627
IMGT
EMBL AC009412 AF136373 AF498964 AJ132694 AJ132695 AK291815 AY279384 BC004247 BC050687 BC107748 BT007121 CH236963 CH878731 DQ165078 M29870 M31467
GenPept AAA36537 AAA36544 AAD30547 AAH04247 AAH50687 AAI07749 AAM21111 AAP35785 AAQ16632 AAS07511 AAS07512 AAZ80485 BAF84504 CAA10732 CAA10733 CAB53579 EAL23718 EAW55044
RNA Seq Atlas 5879