Version 5.4
Homo sapiens Gene: GLUD1
Summary
InnateDB Gene IDBG-81217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLUD1
Gene Name glutamate dehydrogenase 1
Synonyms GDH; GDH1; GLUD
Species Homo sapiens
Ensembl Gene ENSG00000148672
Encoded Proteins
IDBP-81219
glutamate dehydrogenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:87050486-87094866
Strand Reverse strand
Band q23.2
Transcripts
ENST00000277865 ENSP00000277865
ENST00000487058
ENST00000465164
ENST00000474574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0070403 NAD+ binding
GO:0070728 leucine binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006538 glutamate catabolic process
GO:0006541 glutamine metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0021762 substantia nigra development
GO:0032024 positive regulation of insulin secretion
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0072350 tricarboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021794
View Gene Order
ENSBTAG00000007540
Not yet available
Pathways
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00910
Nitrogen metabolism pathway
hsa00471
D-Glutamine and D-glutamate metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt P00367
TrEMBL B3KV55 E9KL48 Q9UQV0
UniProt Splice Variant
Entrez Gene 2746
UniGene Hs.500409
RefSeq NM_005271
HUGO HGNC:4335
OMIM 138130
CCDS CCDS7382
HPRD
IMGT
EMBL AK122685 AL136982 BC040132 BC112946 CH471142 GU727646 J03248 M20867 M37154 X07674 X07769 X66300 X66301 X66302 X66303 X66304 X66305 X66306 X66307 X66308 X66309 X66311 X66312 X67491
GenPept AAA52523 AAA52525 AAA52526 AAH40132 AAI12947 ADU87647 BAG53667 CAA30521 CAA30598 CAA46994 CAA46996 CAA47830 CAI17120 EAW80300 EAW80302 EAW80304
RNA Seq Atlas 2746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca