Homo sapiens Gene: GLUD1
Summary
InnateDB Gene IDBG-81217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLUD1
Gene Name glutamate dehydrogenase 1
Synonyms GDH; GDH1; GLUD;
Species Homo sapiens
Ensembl Gene ENSG00000148672
Encoded Proteins
glutamate dehydrogenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:87050486-87094866
Strand Reverse strand
Band q23.2
Transcripts
ENST00000277865 ENSP00000277865
ENST00000487058
ENST00000465164
ENST00000474574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0070403 NAD+ binding
GO:0070728 leucine binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006538 glutamate catabolic process
GO:0006541 glutamine metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0021762 substantia nigra development
GO:0032024 positive regulation of insulin secretion
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0072350 tricarboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Amino acid synthesis and interconversion (transamination) pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
D-Glutamine and D-glutamate metabolism pathway
Nitrogen metabolism pathway
Proximal tubule bicarbonate reclamation pathway
INOH
Glutamate Glutamine metabolism pathway
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.500409
RefSeq NM_005271
HUGO
OMIM
CCDS CCDS7382
HPRD 11748
IMGT
EMBL
GenPept
RNA Seq Atlas