Homo sapiens Gene: NFATC2
Summary
InnateDB Gene IDBG-81223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFATC2
Gene Name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Synonyms NFAT1; NFATP
Species Homo sapiens
Ensembl Gene ENSG00000101096
Encoded Proteins
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NFATC2 interacts with JUN to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nfatc2 is a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumorigenesis.
Entrez Gene
Summary This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:51386957-51562831
Strand Reverse strand
Band q13.2
Transcripts
ENST00000371564 ENSP00000360619
ENST00000396009 ENSP00000379330
ENST00000414705 ENSP00000396471
ENST00000496054
ENST00000609943 ENSP00000477370
ENST00000610033 ENSP00000477142
ENST00000609507 ENSP00000477342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 40 [view]
Protein-DNA 21 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001816 cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0010628 positive regulation of gene expression
GO:0016477 cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030529 ribonucleoprotein complex
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
KitReceptor pathway
Wnt pathway
TCR pathway
BCR pathway
REACTOME
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
KEGG
VEGF signaling pathway pathway
Wnt signaling pathway pathway
Axon guidance pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
INOH
PID NCI
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Downstream signaling in na´ve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Noncanonical Wnt signaling pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001136021 NM_001258292 NM_001258294 NM_001258295 NM_001258296 NM_001258297 NM_012340 NM_173091 XM_005260413
HUGO
OMIM
CCDS CCDS13437 CCDS33488 CCDS46614 CCDS68156 CCDS68157
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas