InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFATC2

Summary

InnateDB Gene

IDBG-81223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFATC2

Gene Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Synonyms

NFAT1; NFATP

Species

Homo sapiens

Ensembl Gene

ENSG00000101096

Encoded Proteins

IDBP-81225

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

IDBP-238391

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

IDBP-378597

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

IDBP-807937

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

IDBP-807938

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

IDBP-807941

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20557936

NFATC2 interacts with JUN to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.

InnateDB Annotation from Orthologs

Summary

PMID 20557936

[Mus musculus] Nfatc2 is a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumorigenesis.

Entrez Gene

Summary

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:51386957-51562831

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000371564	ENSP00000360619
ENST00000396009	ENSP00000379330
ENST00000414705	ENSP00000396471
ENST00000496054
ENST00000609943	ENSP00000477370
ENST00000610033	ENSP00000477142
ENST00000609507	ENSP00000477342

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	40 [view]
Protein-DNA	21 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001816	cytokine production
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0010628	positive regulation of gene expression
GO:0016477	cell migration
GO:0030890	positive regulation of B cell proliferation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030529	ribonucleoprotein complex
GO:0044798	nuclear transcription factor complex