Homo sapiens Gene: TAP1
Summary
InnateDB Gene IDBG-81568.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAP1
Gene Name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1*0102N; TAP1N;
Species Homo sapiens
Ensembl Gene ENSG00000168394
Encoded Proteins
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32845209-32853978
Strand Reverse strand
Band p21.32
Transcripts
ENST00000354258 ENSP00000346206
ENST00000486332
ENST00000487296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 35 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015197 peptide transporter activity
GO:0016887 ATPase activity
GO:0023029 MHC class Ib protein binding
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006952 defense response
GO:0015833 peptide transport
GO:0019060 intracellular transport of viral protein in host cell
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0046967 cytosol to ER transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042825 TAP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
ABC transporters pathway
Phagosome pathway
Antigen processing and presentation pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
Antigen processing and presentation [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000593 NM_001292022
HUGO
OMIM
CCDS CCDS4758
HPRD 01359
IMGT
EMBL
GenPept
RNA Seq Atlas