Homo sapiens Gene: CDC26 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-81571.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CDC26 | ||||||||||||||||||||||
Gene Name | cell division cycle 26 homolog (S. cerevisiae) | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000176386 | ||||||||||||||||||||||
Encoded Proteins |
cell division cycle 26 homolog (S. cerevisiae)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:113255835-113275589 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q32 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Separation of Sister Chromatids pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular responses to stress pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Cell Cycle pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
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KEGG |
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8NHZ8 | ||||||||||||||||||||||
TrEMBL | A0A024R832 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 246184 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_139286 | ||||||||||||||||||||||
HUGO | HGNC:17839 | ||||||||||||||||||||||
OMIM | 614533 | ||||||||||||||||||||||
CCDS | CCDS6790 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF503918 AL449305 BC042534 BC066300 CH471070 CH471090 | ||||||||||||||||||||||
GenPept | AAH42534 AAH66300 AAM34207 CAI10967 EAW83718 EAW87360 EAW87361 | ||||||||||||||||||||||
RNA Seq Atlas | 246184 | ||||||||||||||||||||||