Version 5.4
Homo sapiens Gene: IRS4
Summary
InnateDB Gene IDBG-82160.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRS4
Gene Name insulin receptor substrate 4
Synonyms IRS-4; PY160
Species Homo sapiens
Ensembl Gene ENSG00000133124
Encoded Proteins
IDBP-82162
insulin receptor substrate 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:108732482-108736409
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372129 ENSP00000361202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 112 [view]
Protein-Protein 111 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054667
View Gene Order
ENSBTAG00000006535
Not yet available
Pathways
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_111102
Signal Transduction pathway
REACT_150210
IGF1R signaling cascade pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04920
Adipocytokine signaling pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460872
RefSeq NM_003604 XM_005262220 XM_006724713
HUGO
OMIM
CCDS CCDS14544
HPRD 04620
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca