Homo sapiens Gene: IRS4
Summary
InnateDB Gene IDBG-82160.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRS4
Gene Name insulin receptor substrate 4
Synonyms IRS-4; PY160;
Species Homo sapiens
Ensembl Gene ENSG00000133124
Encoded Proteins
insulin receptor substrate 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:108732482-108736409
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372129 ENSP00000361202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 112 [view]
Protein-Protein 111 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Leptin pathway
REACTOME
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signal Transduction pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
KEGG
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14654
TrEMBL
UniProt Splice Variant
Entrez Gene 8471
UniGene Hs.460872
RefSeq NM_003604 XM_005262220 XM_006724713
HUGO HGNC:6128
OMIM 300904
CCDS CCDS14544
HPRD 04620
IMGT
EMBL AF007567 AL035425 CH471120
GenPept AAC51738 CAB90290 EAX02682
RNA Seq Atlas 8471