Homo sapiens Gene: LRPAP1
Summary
InnateDB Gene IDBG-8233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRPAP1
Gene Name low density lipoprotein receptor-related protein associated protein 1
Synonyms A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP; MYP23; RAP;
Species Homo sapiens
Ensembl Gene ENSG00000163956
Encoded Proteins
low density lipoprotein receptor-related protein associated protein 1
low density lipoprotein receptor-related protein associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:3506376-3532559
Strand Reverse strand
Band p16.3
Transcripts
ENST00000296325
ENST00000500728 ENSP00000421922
ENST00000515119 ENSP00000421648
ENST00000509198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004873 asialoglycoprotein receptor activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0035473 lipase binding
GO:0048019 receptor antagonist activity
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051082 unfolded protein binding
GO:0070326 very-low-density lipoprotein particle receptor binding
Biological Process
GO:0006457 protein folding
GO:0006898 receptor-mediated endocytosis
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0016192 vesicle-mediated transport
GO:0032091 negative regulation of protein binding
GO:1900116 extracellular negative regulation of signal transduction
GO:1900222 negative regulation of beta-amyloid clearance
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031982 vesicle
GO:0048237 rough endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Integrin signaling pathway [Biocarta view]
PID NCI
Reelin signaling pathway
Signaling events mediated by the Hedgehog family
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.40966
RefSeq NM_002337
HUGO
OMIM
CCDS CCDS3371
HPRD 00082
IMGT
EMBL
GenPept
RNA Seq Atlas