InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PCK1

Summary

InnateDB Gene

IDBG-82362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCK1

Gene Name

phosphoenolpyruvate carboxykinase 1 (soluble)

Synonyms

PEPCK-C; PEPCK1; PEPCKC

Species

Homo sapiens

Ensembl Gene

ENSG00000124253

Encoded Proteins

IDBP-82364

phosphoenolpyruvate carboxykinase 1 (soluble)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:57561080-57568112

Strand

Forward strand

Band

q13.31

Transcripts

ENST00000319441	ENSP00000319814
ENST00000467047
ENST00000475833
ENST00000498194
ENST00000470051
ENST00000485958

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	76 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004611	phosphoenolpyruvate carboxykinase activity
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525	GTP binding
GO:0017076	purine nucleotide binding
GO:0019003	GDP binding
GO:0030145	manganese ion binding
GO:0031406	carboxylic acid binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006107	oxaloacetate metabolic process
GO:0006475	internal protein amino acid acetylation
GO:0006629	lipid metabolic process
GO:0014823	response to activity
GO:0017144	drug metabolic process
GO:0032868	response to insulin
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process
GO:0046327	glycerol biosynthetic process from pyruvate