InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RING1

Summary

InnateDB Gene

IDBG-82377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RING1

Gene Name

ring finger protein 1

Synonyms

RING1A; RNF1

Species

Homo sapiens

Ensembl Gene

ENSG00000204227

Encoded Proteins

IDBP-82379

ring finger protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:33208495-33212722

Strand

Forward strand

Band

p21.32

Transcripts

ENST00000374656	ENSP00000363787
ENST00000478431

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	98 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0016574	histone ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048593	camera-type eye morphogenesis

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0001739	sex chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016607	nuclear speck
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024325

View Gene Order

ENSBTAG00000018884

Not yet available

Pathways

NETPATH

NetPath_3

Notch pathway

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q06587

TrEMBL

A0A024RCR9 B4DVB5

UniProt Splice Variant

Entrez Gene

6015

UniGene

Hs.631989

RefSeq

NM_002931

HUGO

HGNC:10018

OMIM

602045

CCDS

CCDS34424

HPRD

IMGT

EMBL

AK289355 AK301010 AL031228 AL645940 AL713971 AL844527 BC002922 BC051866 BT007352 CH471081 CR547129 CR759733 CR759786 CR847841 Z14000

GenPept

AAH02922 AAH51866 AAP36016 BAF82044 BAG62627 CAA20235 CAA78389 CAI17650 CAI18069 CAI41841 CAI95620 CAQ08246 CAQ10303 CAQ10314 CAQ10355 EAX03683 EAX03684

RNA Seq Atlas

6015