Homo sapiens Gene: RING1
Summary
InnateDB Gene IDBG-82377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RING1
Gene Name ring finger protein 1
Synonyms RING1A; RNF1;
Species Homo sapiens
Ensembl Gene ENSG00000204227
Encoded Proteins
ring finger protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33208495-33212722
Strand Forward strand
Band p21.32
Transcripts
ENST00000374656 ENSP00000363787
ENST00000478431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 99 [view]
Protein-Protein 98 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0016574 histone ubiquitination
GO:0035518 histone H2A monoubiquitination
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048593 camera-type eye morphogenesis
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
REACTOME
Cellular responses to stress pathway
Cellular Senescence pathway
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID BIOCARTA
The prc2 complex sets long-term gene silencing through modification of histone tails [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631989
RefSeq NM_002931
HUGO
OMIM
CCDS CCDS34424
HPRD 03624
IMGT
EMBL
GenPept
RNA Seq Atlas