Version 5.4
Homo sapiens Gene: KIF11
Summary
InnateDB Gene IDBG-82525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF11
Gene Name kinesin family member 11
Synonyms EG5; HKSP; KNSL1; MCLMR; TRIP5
Species Homo sapiens
Ensembl Gene ENSG00000138160
Encoded Proteins
IDBP-82527
kinesin family member 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:92593286-92655395
Strand Forward strand
Band q23.33
Transcripts
ENST00000260731 ENSP00000260731
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007067 mitotic nuclear division
GO:0007100 mitotic centrosome separation
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012443
View Gene Order
ENSBTAG00000009383
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P52732
TrEMBL
UniProt Splice Variant
Entrez Gene 3832
UniGene Hs.8878
RefSeq NM_004523
HUGO HGNC:6388
OMIM 148760
CCDS CCDS7422
HPRD
IMGT
EMBL AL356128 AL360222 BC126211 BC136474 L40372 U37426 X85137
GenPept AAA86132 AAC41739 AAI26212 AAI36475 CAA59449 CAH72288 CAI13671
RNA Seq Atlas 3832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca