Homo sapiens Gene: DAXX
Summary
InnateDB Gene IDBG-82726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAXX
Gene Name death-domain associated protein
Synonyms BING2; DAP6; EAP1;
Species Homo sapiens
Ensembl Gene ENSG00000204209
Encoded Proteins
death-domain associated protein
death-domain associated protein
death-domain associated protein
death-domain associated protein
death-domain associated protein
death-domain associated protein
death-domain associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Daxx interacts with Hdac1 and represses the transcription of Il6 in TLR-triggered macrophages.
Entrez Gene
Summary This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33318558-33329269
Strand Reverse strand
Band p21.32
Transcripts
ENST00000374542 ENSP00000363668
ENST00000266000 ENSP00000266000
ENST00000414083 ENSP00000396876
ENST00000446403 ENSP00000406008
ENST00000453407 ENSP00000408499
ENST00000446511 ENSP00000390008
ENST00000468536
ENST00000477162
ENST00000490173
ENST00000477370
ENST00000498030
ENST00000494082
ENST00000620164 ENSP00000482399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 177 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 177 [view]
Protein-Protein 174 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003714 transcription corepressor activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030295 protein kinase activator activity
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0047485 protein N-terminus binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001934 positive regulation of protein phosphorylation
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007257 activation of JUN kinase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0016032 viral process
GO:0030521 androgen receptor signaling pathway
GO:0031396 regulation of protein ubiquitination
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0097190 apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016605 PML body
GO:0070603 SWI/SNF superfamily-type complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
TGF_beta_Receptor pathway
IL6 pathway
REACTOME
KEGG
MAPK signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
Fas signaling pathway pathway
PID BIOCARTA
Regulation of transcriptional activity by pml [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Stress induction of hsp regulation [Biocarta view]
Fas signaling pathway (cd95) [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
PID NCI
p53 pathway
TGF-beta receptor signaling
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.735641
RefSeq NM_001141969 NM_001141970 NM_001254717 NM_001350 XM_005248860
HUGO
OMIM
CCDS CCDS4776 CCDS59008
HPRD 04424
IMGT
EMBL
GenPept
RNA Seq Atlas