Homo sapiens Gene: TH1L
Summary
InnateDB Gene IDBG-83212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TH1L
Gene Name TH1-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101158
Encoded Proteins
TH1-like (Drosophila)
TH1-like (Drosophila)
negative elongation factor complex member C/D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:58981208-58995133
Strand Forward strand
Band q13.32
Transcripts
ENST00000344018 ENSP00000342300
ENST00000471621
ENST00000492016
ENST00000460601 ENSP00000436783
ENST00000482747
ENST00000464363
ENST00000477741
ENST00000474543
ENST00000478389
ENST00000497935
ENST00000490205
ENST00000479207
ENST00000486263
ENST00000602795 ENSP00000473290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0032021 NELF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Formation of the Early Elongation Complex pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Late Phase of HIV Life Cycle pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
Tat-mediated HIV elongation arrest and recovery pathway
Formation of RNA Pol II elongation complex pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
RNA Polymerase II Transcription pathway
Pausing and recovery of HIV elongation pathway
HIV Life Cycle pathway
HIV elongation arrest and recovery pathway
RNA Polymerase II Pre-transcription Events pathway
Transcription of the HIV genome pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
Formation of the HIV-1 Early Elongation Complex pathway
Gene Expression pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0UI80
UniProt Splice Variant
Entrez Gene 51497
UniGene
RefSeq NM_198976
HUGO HGNC:15934
OMIM 605297
CCDS CCDS13473
HPRD
IMGT
EMBL AF161479 AJ238374 AJ238375 AJ238379 AK001316 AK023310 AK023927 AK293410 AL109840 BC014952 CH471077
GenPept AAF29094 AAH14952 BAA91618 BAB14519 BAB14729 BAG56917 CAB64337 CAB64339 CAB64373 CAC09368 EAW75452 EAW75453 EAW75454
RNA Seq Atlas 51497