Homo sapiens Gene: UBE2A
Summary
InnateDB Gene IDBG-83741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2A
Gene Name ubiquitin-conjugating enzyme E2A
Synonyms HHR6A; MRXS30; MRXSN; RAD6A; UBC2;
Species Homo sapiens
Ensembl Gene ENSG00000077721
Encoded Proteins
ubiquitin-conjugating enzyme E2A
ubiquitin-conjugating enzyme E2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Jul 2008]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:119574538-119584418
Strand Forward strand
Band q24
Transcripts
ENST00000371569
ENST00000346330 ENSP00000335027
ENST00000371558 ENSP00000360613
ENST00000469205
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001701 in utero embryonic development
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008284 positive regulation of cell proliferation
GO:0009411 response to UV
GO:0033522 histone H2A ubiquitination
GO:0051865 protein autoubiquitination
GO:0060135 maternal process involved in female pregnancy
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0001741 XY body
GO:0005829 cytosol
GO:0033503 HULC complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Fibrinolysis pathway [Biocarta view]
Gamma-aminobutyric acid receptor life cycle pathway [Biocarta view]
Proteasome complex [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
Hypoxia and p53 in the cardiovascular system [Biocarta view]
Sumoylation as a mechanism to modulate ctbp-dependent gene responses [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.379466
RefSeq NM_001282161 NM_003336 NM_181762
HUGO
OMIM
CCDS CCDS14580 CCDS14581
HPRD 02422
IMGT
EMBL
GenPept
RNA Seq Atlas