Homo sapiens Gene: SEPT6
Summary
InnateDB Gene IDBG-83838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT6
Gene Name septin 6
Synonyms SEP2; SEPT2;
Species Homo sapiens
Ensembl Gene ENSG00000125354
Encoded Proteins
septin 6
septin 6
septin 6
septin 6
septin 6
septin 6
septin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:119615724-119693370
Strand Reverse strand
Band q24
Transcripts
ENST00000360156 ENSP00000353278
ENST00000354228 ENSP00000346169
ENST00000354416 ENSP00000346397
ENST00000343984 ENSP00000341524
ENST00000394610 ENSP00000378108
ENST00000460411 ENSP00000435818
ENST00000489216 ENSP00000418715
ENST00000467310
ENST00000481072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0000910 cytokinesis
GO:0007049 cell cycle
GO:0016032 viral process
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005819 spindle
GO:0008021 synaptic vesicle
GO:0030496 midbody
GO:0031105 septin complex
GO:0032154 cleavage furrow
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q14141
TrEMBL Q541S4 Q548C9
UniProt Splice Variant
Entrez Gene 23157
UniGene Hs.496666 Hs.598119
RefSeq NM_145802 NM_145800 NM_015129 NM_145799 XM_006724749 XM_006724748 XM_006724750 XM_005262400
HUGO HGNC:15848
OMIM 300683
CCDS CCDS14583 CCDS14585 CCDS14584
HPRD 06716
IMGT
EMBL AC004913 AC005052 AF397023 AF403058 AF403059 AF403060 AF403061 AF403062 AK290977 AK299273 AL355348 AY005981 AY034177 BC009291 BC011922 BC036240 CH471161 D50918
GenPept AAF97496 AAH09291 AAH11922 AAH36240 AAK61492 AAK98547 AAK98548 AAK98549 AAK98550 AAK98551 AAN76547 BAA09477 BAF83666 BAG61293 CAI41426 EAW89854 EAW89855 EAW89856
RNA Seq Atlas 23157