Version 5.4
Homo sapiens Gene: SCLY
Summary
InnateDB Gene IDBG-84394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCLY
Gene Name selenocysteine lyase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132330
Encoded Proteins
IDBP-84396
selenocysteine lyase
IDBP-292857
selenocysteine lyase
IDBP-389514
selenocysteine lyase
IDBP-389515
selenocysteine lyase
IDBP-389516
selenocysteine lyase
IDBP-389517
selenocysteine lyase
IDBP-389518
selenocysteine lyase
IDBP-389519
selenocysteine lyase
IDBP-389520
selenocysteine lyase
IDBP-389521
selenocysteine lyase
IDBP-389522
selenocysteine lyase
IDBP-389524
selenocysteine lyase
IDBP-389525
selenocysteine lyase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:238060889-238099413
Strand Forward strand
Band q37.3
Transcripts
ENST00000254663 ENSP00000254663
ENST00000409736 ENSP00000387162
ENST00000413463 ENSP00000414165
ENST00000446202 ENSP00000391361
ENST00000423324 ENSP00000392517
ENST00000412508 ENSP00000416344
ENST00000443532 ENSP00000406710
ENST00000416757 ENSP00000404473
ENST00000431487 ENSP00000402078
ENST00000437134 ENSP00000404444
ENST00000450965 ENSP00000414053
ENST00000440143 ENSP00000405907
ENST00000433750 ENSP00000401401
ENST00000480357
ENST00000497256
ENST00000487197
ENST00000480859
ENST00000482031
ENST00000497951
ENST00000463433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0009000 selenocysteine lyase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006520 cellular amino acid metabolic process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0032868 response to insulin
GO:1900408 negative regulation of cellular response to oxidative stress
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026307
View Gene Order
ENSBTAG00000017826
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.637910 Hs.731909
RefSeq NM_016510
HUGO
OMIM
CCDS CCDS2524
HPRD 15303
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca