Homo sapiens Gene: HDAC4
Summary
InnateDB Gene IDBG-84594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC4
Gene Name histone deacetylase 4
Synonyms AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA;
Species Homo sapiens
Ensembl Gene ENSG00000068024
Encoded Proteins
histone deacetylase 4
histone deacetylase 4
histone deacetylase 4
histone deacetylase 4
histone deacetylase 4
histone deacetylase 4
histone deacetylase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:239048168-239401654
Strand Reverse strand
Band q37.3
Transcripts
ENST00000345617 ENSP00000264606
ENST00000430200 ENSP00000410551
ENST00000445704 ENSP00000391226
ENST00000454542 ENSP00000405226
ENST00000446876 ENSP00000392912
ENST00000494800
ENST00000487617
ENST00000463007
ENST00000495497
ENST00000493582
ENST00000460235
ENST00000461113
ENST00000496347
ENST00000535493
ENST00000553145
ENST00000544989 ENSP00000438111
ENST00000543185 ENSP00000440481
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 253 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 253 [view]
Protein-Protein 182 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 67 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0030955 potassium ion binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0033613 activating transcription factor binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491 repressing transcription factor binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0002076 osteoblast development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006954 inflammatory response
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010832 negative regulation of myotube differentiation
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0030183 B cell differentiation
GO:0033235 positive regulation of protein sumoylation
GO:0034983 peptidyl-lysine deacetylation
GO:0042113 B cell activation
GO:0042493 response to drug
GO:0043393 regulation of protein binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045668 negative regulation of osteoblast differentiation
GO:0045820 negative regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048742 regulation of skeletal muscle fiber development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 regulation of striated muscle cell differentiation
GO:0070555 response to interleukin-1
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031594 neuromuscular junction
GO:0031672 A band
GO:0042641 actomyosin
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
INOH
TGF-beta signaling pathway
PID BIOCARTA
Sumoylation by ranbp2 regulates transcriptional repression [Biocarta view]
PID NCI
Validated nuclear estrogen receptor alpha network
Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class III
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.20516 Hs.599215
RefSeq NM_006037 XM_006712877 XM_006712878 XM_006712879 XM_006712880
HUGO
OMIM
CCDS CCDS2529
HPRD 05610
IMGT
EMBL
GenPept
RNA Seq Atlas