|Homo sapiens Gene: TNFRSF4|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||tumor necrosis factor receptor superfamily, member 4|
|Synonyms||ACT35; CD134; IMD16; OX40; TXGP1L;|
tumor necrosis factor receptor superfamily, member 4
|Useful resources||Stemformatics EHFPI ImmGen|
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 1:1211326-1214138|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Downstream signaling in na´ve CD8+ T cells
|UniProt Splice Variant|
|RNA Seq Atlas|