Version 5.4
Homo sapiens Gene: PPP6C
Summary
InnateDB Gene IDBG-85080.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP6C
Gene Name protein phosphatase 6, catalytic subunit
Synonyms PP6; PP6C
Species Homo sapiens
Ensembl Gene ENSG00000119414
Encoded Proteins
IDBP-85082
protein phosphatase 6, catalytic subunit
IDBP-380210
protein phosphatase 6, catalytic subunit
IDBP-380211
protein phosphatase 6, catalytic subunit
IDBP-380213
protein phosphatase 6, catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:125146573-125189939
Strand Reverse strand
Band q33.3
Transcripts
ENST00000373547 ENSP00000362648
ENST00000451402 ENSP00000392147
ENST00000415905 ENSP00000411744
ENST00000456642 ENSP00000416287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 65 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026753
View Gene Order
ENSBTAG00000008033
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_13
IL1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5T1S7
UniProt Splice Variant
Entrez Gene 5537
UniGene Hs.594307 Hs.601402 Hs.743623
RefSeq NM_001123355 NM_001123369 NM_002721 XM_006717175
HUGO HGNC:9323
OMIM 612725
CCDS CCDS48018 CCDS48019 CCDS6861
HPRD 02141
IMGT
EMBL AL445930
GenPept
RNA Seq Atlas 5537

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca