Homo sapiens Gene: XIAP
Summary
InnateDB Gene IDBG-85142.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XIAP
Gene Name X-linked inhibitor of apoptosis
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101966
Encoded Proteins
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
XIAP regulates cytosol-specific innate immunity to Listeria infection.
XIAP interacts with NOD1 and NOD2 and mediates NOD signalling via interaction with RIPK2.
XIAP and its E3 ligase activity promote transforming growth factor-{beta}-mediated NF-kappaB activation during breast cancer progression.
X-linked inhibitor of apoptosis protein (XIAP) in a complex with survivin, a physiological substrate for granzyme M (GzmM), act to inhibit caspase activation.
XIAP facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Xiap facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
Entrez Gene
Summary This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:123859724-123913979
Strand Forward strand
Band q25
Transcripts
ENST00000355640 ENSP00000347858
ENST00000371199 ENSP00000360242
ENST00000422098 ENSP00000405529
ENST00000430625 ENSP00000400637
ENST00000434753 ENSP00000395230
ENST00000481776
ENST00000497906
ENST00000468691
ENST00000497640
ENST00000468503
ENST00000496602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 221 [view]
Protein-Protein 213 [view]
Protein-DNA 2 [view]
Protein-RNA 4 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0030510 regulation of BMP signaling pathway
GO:0031398 positive regulation of protein ubiquitination
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0050727 regulation of inflammatory response
GO:0055070 copper ion homeostasis
GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902530 positive regulation of protein linear polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
SMAC-mediated apoptotic response pathway
Signaling by Wnt pathway
SMAC-mediated dissociation of IAP:caspase complexes pathway
deactivation of the beta-catenin transactivating complex pathway
Apoptosis pathway
Signal Transduction pathway
Apoptotic factor-mediated response pathway
TCF dependent signaling in response to WNT pathway
SMAC binds to IAPs pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Intrinsic Pathway for Apoptosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Ubiquitin mediated proteolysis pathway
Apoptosis pathway
Focal adhesion pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
BMP receptor signaling
TGF-beta receptor signaling
Cross-References
SwissProt P98170
TrEMBL B1AKU2
UniProt Splice Variant
Entrez Gene 331
UniGene Hs.356076 Hs.598042 Hs.626277 Hs.718045
RefSeq NM_001204401 NM_001167 XM_006724754
HUGO HGNC:592
OMIM 300079
CCDS CCDS14606
HPRD 02094
IMGT
EMBL AL022156 AL121601 AL591583 AY886519 BC032729 CH471107 U32974 U45880
GenPept AAC50373 AAC50518 AAH32729 AAW62257 CAB95312 EAX11858 EAX11859 EAX11860 EAX11861
RNA Seq Atlas 331