Homo sapiens Gene: HSPA5
Summary
InnateDB Gene IDBG-85148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA5
Gene Name heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Synonyms BIP; GRP78; HEL-S-89n; MIF2;
Species Homo sapiens
Ensembl Gene ENSG00000044574
Encoded Proteins
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:125234853-125241330
Strand Reverse strand
Band q33.3
Transcripts
ENST00000324460 ENSP00000324173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 284 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 284 [view]
Protein-Protein 283 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0043022 ribosome binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051787 misfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0002576 platelet degranulation
GO:0006200 ATP catabolic process
GO:0006983 ER overload response
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007596 blood coagulation
GO:0021589 cerebellum structural organization
GO:0021680 cerebellar Purkinje cell layer development
GO:0021762 substantia nigra development
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031398 positive regulation of protein ubiquitination
GO:0034976 response to endoplasmic reticulum stress
GO:0035437 maintenance of protein localization in endoplasmic reticulum
GO:0042149 cellular response to glucose starvation
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060904 regulation of protein folding in endoplasmic reticulum
GO:0071236 cellular response to antibiotic
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0008180 COP9 signalosome
GO:0009986 cell surface
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030496 midbody
GO:0034663 endoplasmic reticulum chaperone complex
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
AndrogenReceptor pathway
TNFalpha pathway
RANKL pathway
TSH pathway
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
PERK regulates gene expression pathway
Immune System pathway
ATF6-alpha activates chaperone genes pathway
Response to elevated platelet cytosolic Ca2+ pathway
Class I MHC mediated antigen processing & presentation pathway
ATF6-alpha activates chaperones pathway
Hemostasis pathway
KEGG
Protein export pathway
Protein processing in endoplasmic reticulum pathway
Antigen processing and presentation pathway
Prion diseases pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619186 Hs.743241
RefSeq NM_005347
HUGO
OMIM
CCDS CCDS6863
HPRD 00682
IMGT
EMBL
GenPept
RNA Seq Atlas