Homo sapiens Gene: SSTR5
Summary
InnateDB Gene IDBG-8518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSTR5
Gene Name somatostatin receptor 5
Synonyms SS-5-R;
Species Homo sapiens
Ensembl Gene ENSG00000162009
Encoded Proteins
somatostatin receptor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1078781-1080142
Strand Forward strand
Band p13.3
Transcripts
ENST00000293897 ENSP00000293897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0008285 negative regulation of cell proliferation
GO:0032467 positive regulation of cytokinesis
GO:0038170 somatostatin signaling pathway
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P35346
TrEMBL
UniProt Splice Variant
Entrez Gene 6755
UniGene Hs.449840
RefSeq NM_001053 NM_001172560 XM_006720936
HUGO HGNC:11334
OMIM 182455
CCDS CCDS10429
HPRD
IMGT
EMBL AE006466 AL031713 AY081193 CH471112 D16827 L14865
GenPept AAA20828 AAK61266 AAL88744 BAA04107 EAW85687
RNA Seq Atlas 6755