Homo sapiens Gene: GNB1
Summary
InnateDB Gene IDBG-85988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNB1
Gene Name guanine nucleotide binding protein (G protein), beta polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000078369
Encoded Proteins
guanine nucleotide binding protein (G protein), beta polypeptide 1
guanine nucleotide binding protein (G protein), beta polypeptide 1
guanine nucleotide binding protein (G protein), beta polypeptide 1
guanine nucleotide binding protein (G protein), beta polypeptide 1
guanine nucleotide binding protein (G protein), beta polypeptide 1
guanine nucleotide binding protein (G protein), beta polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1785285-1891117
Strand Reverse strand
Band p36.33
Transcripts
ENST00000378609 ENSP00000367872
ENST00000439272 ENSP00000399741
ENST00000434686 ENSP00000392765
ENST00000437146 ENSP00000416651
ENST00000461893
ENST00000471354
ENST00000472614
ENST00000607589
ENST00000615252 ENSP00000483532
ENST00000610897 ENSP00000481878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 118 [view]
Protein-Protein 118 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0030507 spectrin binding
GO:0031702 type 1 angiotensin receptor binding
GO:0032403 protein complex binding
GO:0051020 GTPase binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0007603 phototransduction, visible light
GO:0008283 cell proliferation
GO:0010659 cardiac muscle cell apoptotic process
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0044281 small molecule metabolic process
GO:0050909 sensory perception of taste
GO:0060041 retina development in camera-type eye
GO:0071377 cellular response to glucagon stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071456 cellular response to hypoxia
GO:0071870 cellular response to catecholamine stimulus
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005622 intracellular
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042622 photoreceptor outer segment membrane
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
GO:0097381 photoreceptor disc membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
ADP signalling through P2Y purinoceptor 12 pathway
Presynaptic function of Kainate receptors pathway
Transmembrane transport of small molecules pathway
G alpha (12/13) signalling events pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Activation of the phototransduction cascade pathway
beta-catenin independent WNT signaling pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Prostacyclin signalling through prostacyclin receptor pathway
GABA receptor activation pathway
Glucagon signaling in metabolic regulation pathway
G protein gated Potassium channels pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Glucagon-type ligand receptors pathway
G-protein activation pathway
Inwardly rectifying K+ channels pathway
Activation of Kainate Receptors upon glutamate binding pathway
Diseases associated with visual transduction pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Platelet homeostasis pathway
G alpha (z) signalling events pathway
Potassium Channels pathway
GABA B receptor activation pathway
Visual phototransduction pathway
Thromboxane signalling through TP receptor pathway
Transmission across Chemical Synapses pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
ADP signalling through P2Y purinoceptor 1 pathway
G beta:gamma signalling through PLC beta pathway
GPCR ligand binding pathway
The phototransduction cascade pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Signal amplification pathway
Activation of G protein gated Potassium channels pathway
Class B/2 (Secretin family receptors) pathway
Aquaporin-mediated transport pathway
Disease pathway
Hemostasis pathway
Olfactory Signaling Pathway pathway
KEGG
Chemokine signaling pathway pathway
Taste transduction pathway
Phototransduction pathway
INOH
PID BIOCARTA
Regulation of spermatogenesis by crem [Biocarta view]
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Signaling pathway from g-protein families [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Attenuation of gpcr signaling [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
G-protein signaling through tubby proteins [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Visual signal transduction [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
Nongenotropic Androgen signaling
Rapid glucocorticoid signaling
Thromboxane A2 receptor signaling
IL8- and CXCR2-mediated signaling events
LPA receptor mediated events
CXCR4-mediated signaling events
IL8- and CXCR1-mediated signaling events
PAR1-mediated thrombin signaling events
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
PAR4-mediated thrombin signaling events
Hedgehog signaling events mediated by Gli proteins
CXCR3-mediated signaling events
Visual signal transduction: Rods
Cross-References
SwissProt
TrEMBL A0A024R056 B1AKQ8 B3KVK2 F6UT28 Q71UM6 Q71UM7
UniProt Splice Variant
Entrez Gene 2782
UniGene
RefSeq NM_001282539 NM_002074 NM_001282538
HUGO HGNC:4396
OMIM 139380
CCDS CCDS34 CCDS72685
HPRD
IMGT
EMBL AF070597 AF070603 AF501882 AK122949 AL031282 AL109917 BC004186 BC005888 BC008991 BC114618 BT007305 CH471183 CR456784 M36430 X04526
GenPept AAA63265 AAC28652 AAC28655 AAH04186 AAH05888 AAH08991 AAI14619 AAM15918 AAP35969 BAG53814 CAA28207 CAG33065 CAI20029 CAI95654 EAW56147 EAW56148 EAW56149 EAW56150
RNA Seq Atlas 2782