Version 5.4
Homo sapiens Gene: GNB1
Summary
InnateDB Gene IDBG-85988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNB1
Gene Name guanine nucleotide binding protein (G protein), beta polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000078369
Encoded Proteins
IDBP-85990
guanine nucleotide binding protein (G protein), beta polypeptide 1
IDBP-362525
guanine nucleotide binding protein (G protein), beta polypeptide 1
IDBP-362526
guanine nucleotide binding protein (G protein), beta polypeptide 1
IDBP-362532
guanine nucleotide binding protein (G protein), beta polypeptide 1
IDBP-808652
guanine nucleotide binding protein (G protein), beta polypeptide 1
IDBP-808653
guanine nucleotide binding protein (G protein), beta polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1785285-1891117
Strand Reverse strand
Band p36.33
Transcripts
ENST00000378609 ENSP00000367872
ENST00000439272 ENSP00000399741
ENST00000434686 ENSP00000392765
ENST00000437146 ENSP00000416651
ENST00000461893
ENST00000471354
ENST00000472614
ENST00000607589
ENST00000615252 ENSP00000483532
ENST00000610897 ENSP00000481878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 118 [view]
Protein-Protein 118 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0030507 spectrin binding
GO:0031702 type 1 angiotensin receptor binding
GO:0032403 protein complex binding
GO:0051020 GTPase binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0007603 phototransduction, visible light
GO:0008283 cell proliferation
GO:0010659 cardiac muscle cell apoptotic process
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0044281 small molecule metabolic process
GO:0050909 sensory perception of taste
GO:0060041 retina development in camera-type eye
GO:0071377 cellular response to glucagon stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071456 cellular response to hypoxia
GO:0071870 cellular response to catecholamine stimulus
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005622 intracellular
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042622 photoreceptor outer segment membrane
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
GO:0097381 photoreceptor disc membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029064
View Gene Order
ENSBTAG00000000215
Not yet available
Pathways
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15488
Olfactory Signaling Pathway pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_172761
Ca2+ pathway pathway
REACT_163932
Activation of the phototransduction cascade pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_75908
Potassium Channels pathway
REACT_160125
Visual phototransduction pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21340
GPCR ligand binding pathway
REACT_163722
The phototransduction cascade pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_20524
Signal amplification pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04742
Taste transduction pathway
hsa04062
Chemokine signaling pathway pathway
hsa04744
Phototransduction pathway
INOH
PID NCI
ar_nongenomic_pathway
Nongenotropic Androgen signaling
rapid_gr_pathway
Rapid glucocorticoid signaling
txa2pathway
Thromboxane A2 receptor signaling
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
lysophospholipid_pathway
LPA receptor mediated events
cxcr4_pathway
CXCR4-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
hdac_classii_pathway
Signaling events mediated by HDAC Class II
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
thrombin_par4_pathway
PAR4-mediated thrombin signaling events
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
cxcr3pathway
CXCR3-mediated signaling events
rhodopsin_pathway
Visual signal transduction: Rods
Cross-References
SwissProt
TrEMBL B3KVK2 Q71UM6 Q71UM7
UniProt Splice Variant
Entrez Gene 2782
UniGene
RefSeq NM_001282538 NM_001282539 NM_002074
HUGO HGNC:4396
OMIM 139380
CCDS CCDS72685 CCDS34
HPRD
IMGT
EMBL AF070597 AF070603 AK122949
GenPept AAC28652 AAC28655 BAG53814
RNA Seq Atlas 2782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca