Homo sapiens Gene: EEF1A2
Summary
InnateDB Gene IDBG-86175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF1A2
Gene Name eukaryotic translation elongation factor 1 alpha 2
Synonyms EEF1AL; EF-1-alpha-2; EF1A; HS1; STN; STNL;
Species Homo sapiens
Ensembl Gene ENSG00000101210
Encoded Proteins
eukaryotic translation elongation factor 1 alpha 2
eukaryotic translation elongation factor 1 alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63488013-63499315
Strand Reverse strand
Band q13.33
Transcripts
ENST00000217182 ENSP00000217182
ENST00000298049 ENSP00000298049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, nucleic acid binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0010035 response to inorganic substance
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Translation pathway
Metabolism of proteins pathway
Eukaryotic Translation Elongation pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q05639
TrEMBL
UniProt Splice Variant
Entrez Gene 1917
UniGene Hs.433839
RefSeq NM_001958
HUGO HGNC:3192
OMIM 602959
CCDS CCDS13522
HPRD
IMGT
EMBL AB451389 AF163763 AL121829 BC000432 BC110409 CH471077 L10340 X70940
GenPept AAA91835 AAF80488 AAH00432 AAI10410 BAG70203 CAA50280 CAC15522 EAW75260
RNA Seq Atlas 1917