InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PKD2L1

Summary

InnateDB Gene

IDBG-86420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKD2L1

Gene Name

polycystic kidney disease 2-like 1

Synonyms

PCL; PKD2L; PKDL; TRPP3

Species

Homo sapiens

Ensembl Gene

ENSG00000107593

Encoded Proteins

IDBP-86422

polycystic kidney disease 2-like 1

IDBP-599871

polycystic kidney disease 2-like 1

IDBP-601483

polycystic kidney disease 2-like 1

IDBP-584660

polycystic kidney disease 2-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:100288154-100330486

Strand

Reverse strand

Band

q24.31

Transcripts

ENST00000318222	ENSP00000325296
ENST00000465680	ENSP00000434019
ENST00000528248	ENSP00000436514
ENST00000532547	ENSP00000434224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005272	sodium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008324	cation transmembrane transporter activity
GO:0015269	calcium-activated potassium channel activity
GO:0033040	sour taste receptor activity
GO:0042802	identical protein binding
GO:0051371	muscle alpha-actinin binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0001581	detection of chemical stimulus involved in sensory perception of sour taste
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007224	smoothened signaling pathway
GO:0035725	sodium ion transmembrane transport
GO:0050915	sensory perception of sour taste
GO:0050982	detection of mechanical stimulus
GO:0055085	transmembrane transport
GO:0070207	protein homotrimerization
GO:0070588	calcium ion transmembrane transport
GO:0071468	cellular response to acidity
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031513	nonmotile primary cilium
GO:0034704	calcium channel complex
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037578

View Gene Order

ENSBTAG00000010742

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

9033

UniGene

Hs.159241

RefSeq

NM_001253837 NM_016112

HUGO

HGNC:9011

OMIM

604532

CCDS

CCDS7492

HPRD

16063

IMGT

EMBL

GenPept

RNA Seq Atlas

9033