Version 5.4
Homo sapiens Gene: BYSL
Summary
InnateDB Gene IDBG-86968.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BYSL
Gene Name bystin-like
Synonyms BYSTIN
Species Homo sapiens
Ensembl Gene ENSG00000112578
Encoded Proteins
IDBP-86970
bystin-like
IDBP-86972
bystin-like
IDBP-474727
bystin-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41921188-41933046
Strand Forward strand
Band p21.1
Transcripts
ENST00000230340 ENSP00000230340
ENST00000372996 ENSP00000362087
ENST00000494032
ENST00000489290 ENSP00000417813
ENST00000475702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 95 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001701 in utero embryonic development
GO:0001825 blastocyst formation
GO:0001829 trophectodermal cell differentiation
GO:0007155 cell adhesion
GO:0007565 female pregnancy
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023988
View Gene Order
ENSBTAG00000010101
Not yet available
Cross-References
SwissProt
TrEMBL F8WBL2
UniProt Splice Variant
Entrez Gene 705
UniGene
RefSeq NM_004053
HUGO HGNC:1157
OMIM 603871
CCDS CCDS34450
HPRD 04848
IMGT
EMBL AL160163
GenPept
RNA Seq Atlas 705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca