Homo sapiens Gene: KCNAB2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-87190.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | KCNAB2 | ||||||||||||||||||||||
Gene Name | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | ||||||||||||||||||||||
Synonyms | AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000069424 | ||||||||||||||||||||||
Encoded Proteins |
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:5991466-6101193 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p36.31 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Voltage gated Potassium channels pathway
Neuronal System pathway
Potassium Channels pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | K7EKU4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8514 | ||||||||||||||||||||||
UniGene | Hs.440497 Hs.735032 | ||||||||||||||||||||||
RefSeq | NM_001199860 NM_001199861 NM_001199862 NM_001199863 NM_003636 NM_172130 XM_005263512 XM_005263513 XM_005263514 | ||||||||||||||||||||||
HUGO | HGNC:6229 | ||||||||||||||||||||||
OMIM | 601142 | ||||||||||||||||||||||
CCDS | CCDS55 CCDS55570 CCDS55571 CCDS56 | ||||||||||||||||||||||
HPRD | 03090 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL035406 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 8514 | ||||||||||||||||||||||