InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LCN2

Summary

InnateDB Gene

IDBG-87415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCN2

Gene Name

lipocalin 2

Synonyms

24p3; MSFI; NGAL

Species

Homo sapiens

Ensembl Gene

ENSG00000148346

Encoded Proteins

IDBP-87417

lipocalin 2

IDBP-87421

lipocalin 2

IDBP-87423

lipocalin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25398327

LCN2 is secreted by the urinary tract mucosa in response to uropathogenic E. coli challenge and acts in innate immune defences as a colonization barrier.

InnateDB Annotation from Orthologs

Summary

PMID 26190773

[Mus musculus] Macrophage iron regulatory proteins Aco1 and Ireb2 are protective against Salmonella by promoting the induction of Lcn2, a host antimicrobial factor that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:128149071-128153455

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000373017	ENSP00000362108
ENST00000277480	ENSP00000277480
ENST00000372998	ENSP00000362089
ENST00000470902
ENST00000487719
ENST00000488391
ENST00000494317

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	7 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005215	transporter activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0036094	small molecule binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006979	response to oxidative stress
GO:0009615	response to virus
GO:0009617	response to bacterium
GO:0009635	response to herbicide
GO:0009636	response to toxic substance
GO:0010628	positive regulation of gene expression
GO:0015891	siderophore transport
GO:0031346	positive regulation of cell projection organization
GO:0031667	response to nutrient levels
GO:0031669	cellular response to nutrient levels
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0070207	protein homotrimerization
GO:0070301	cellular response to hydrogen peroxide
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026822

View Gene Order

ENSBTAG00000014149

Not yet available

Pathways

NETPATH

REACTOME

REACT_25060

Iron uptake and transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_267716

Orphan transporters pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.204238

RefSeq

NM_005564

HUGO

OMIM

CCDS

CCDS6892

HPRD

02551

IMGT

EMBL

GenPept

RNA Seq Atlas