Version 5.4
Homo sapiens Gene: GNMT
Summary
InnateDB Gene IDBG-87449.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNMT
Gene Name glycine N-methyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124713
Encoded Proteins
IDBP-87451
glycine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42960758-42963880
Strand Forward strand
Band p21.1
Transcripts
ENST00000372808 ENSP00000361894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005542 folic acid binding
GO:0008168 methyltransferase activity
GO:0016594 glycine binding
GO:0017174 glycine N-methyltransferase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006464 cellular protein modification process
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0008152 metabolic process
GO:0032259 methylation
GO:0046500 S-adenosylmethionine metabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002769
View Gene Order
ENSBTAG00000005530
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt Q14749
TrEMBL V9HW60
UniProt Splice Variant
Entrez Gene 27232
UniGene
RefSeq NM_018960
HUGO HGNC:4415
OMIM 606628
CCDS CCDS4876
HPRD
IMGT
EMBL AF101475 AF101477 AL158815 BC032627 CH471081 FJ224320 X62250
GenPept AAF78289 AAF78290 AAH32627 ACI46012 CAA44164 CAI19462 EAX04124
RNA Seq Atlas 27232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca