Version 5.4
Homo sapiens Gene: MGEA5
Summary
InnateDB Gene IDBG-87480.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGEA5
Gene Name meningioma expressed antigen 5 (hyaluronidase)
Synonyms MEA5; NCOAT; OGA;
Species Homo sapiens
Ensembl Gene ENSG00000198408
Encoded Proteins
IDBP-87482
meningioma expressed antigen 5 (hyaluronidase)
IDBP-87484
meningioma expressed antigen 5 (hyaluronidase)
IDBP-87486
meningioma expressed antigen 5 (hyaluronidase)
IDBP-384711
meningioma expressed antigen 5 (hyaluronidase)
IDBP-384712
meningioma expressed antigen 5 (hyaluronidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:101784443-101818465
Strand Reverse strand
Band q24.32
Transcripts
ENST00000361464 ENSP00000354850
ENST00000357797 ENSP00000350445
ENST00000370094 ENSP00000359112
ENST00000439817 ENSP00000409973
ENST00000429860 ENSP00000414235
ENST00000462994
ENST00000482611
ENST00000494347
ENST00000479811
ENST00000461645
ENST00000492204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 28 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0004415 hyalurononglucosaminidase activity
Biological Process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006516 glycoprotein catabolic process
GO:0006612 protein targeting to membrane
GO:0007568 aging
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010616 negative regulation of cardiac muscle adaptation
GO:0031343 positive regulation of cell killing
GO:0032024 positive regulation of insulin secretion
GO:0043243 positive regulation of protein complex disassembly
GO:0045862 positive regulation of proteolysis
GO:0046060 dATP metabolic process
GO:0046326 positive regulation of glucose import
GO:0048545 response to steroid hormone
GO:0051054 positive regulation of DNA metabolic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051928 positive regulation of calcium ion transport
GO:0060051 negative regulation of protein glycosylation
GO:0060124 positive regulation of growth hormone secretion
GO:0070265 necrotic cell death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000025220
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000016336
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL H7C3X0
UniProt Splice Variant
Entrez Gene 10724
UniGene Hs.500842 Hs.600565 Hs.610535 Hs.713868 Hs.740141
RefSeq NM_012215 NM_001142434
HUGO HGNC:7056
OMIM 604039
CCDS CCDS7520 CCDS44471
HPRD 04949
IMGT
EMBL AC010789
GenPept
RNA Seq Atlas 10724

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca