Version 5.4
Homo sapiens Gene: KLHDC3
Summary
InnateDB Gene IDBG-87610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHDC3
Gene Name kelch domain containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124702
Encoded Proteins
IDBP-87612
kelch domain containing 3
IDBP-87614
kelch domain containing 3
IDBP-87616
kelch domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43014103-43021298
Strand Forward strand
Band p21.1
Transcripts
ENST00000326974 ENSP00000313995
ENST00000332245 ENSP00000331562
ENST00000244670 ENSP00000244670
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007131 reciprocal meiotic recombination
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063576
View Gene Order
ENSBTAG00000012746
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8W6A4
UniProt Splice Variant
Entrez Gene 116138
UniGene Hs.412468 Hs.740012
RefSeq NM_057161
HUGO HGNC:20704
OMIM 611248
CCDS CCDS4880
HPRD 13922
IMGT
EMBL AL136304
GenPept
RNA Seq Atlas 116138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca