Homo sapiens Gene: PRPF6
Summary
InnateDB Gene IDBG-87633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRPF6
Gene Name PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
Synonyms ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60; SNRNP102; TOM; U5-102K;
Species Homo sapiens
Ensembl Gene ENSG00000101161
Encoded Proteins
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63981135-64033100
Strand Forward strand
Band q13.33
Transcripts
ENST00000266079 ENSP00000266079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 99 [view]
Protein-Protein 97 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0044822 poly(A) RNA binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O94906
TrEMBL
UniProt Splice Variant
Entrez Gene 24148
UniGene Hs.31334
RefSeq NM_012469
HUGO HGNC:15860
OMIM 613979
CCDS CCDS13550
HPRD
IMGT
EMBL AB019219 AF026031 AF221842 AK001554 AK314310 AL118506 AL137320 AL355803 AL356790 BC001666
GenPept AAD01798 AAF66128 AAH01666 BAA37140 BAG36962 BAG50938 CAB70695 CAC16610 CAH71582 CAI21906
RNA Seq Atlas 24148