InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OPRL1

Summary

InnateDB Gene

IDBG-87828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPRL1

Gene Name

opiate receptor-like 1

Synonyms

KOR-3; NOCIR; OOR; ORL1

Species

Homo sapiens

Ensembl Gene

ENSG00000125510

Encoded Proteins

IDBP-87832

opiate receptor-like 1

IDBP-87834

opiate receptor-like 1

IDBP-87836

opiate receptor-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:64080173-64100643

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000336866	ENSP00000336843
ENST00000355631	ENSP00000347848
ENST00000349451	ENSP00000336764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001626	nociceptin receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007600	sensory perception
GO:0007610	behavior
GO:0019233	sensory perception of pain
GO:0038003	opioid receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027584

View Gene Order

ENSBTAG00000045701

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P41146

TrEMBL

UniProt Splice Variant

Entrez Gene

4987

UniGene

Hs.2859

RefSeq

NM_000913 NM_001200019 NM_182647 XM_005260206 XM_006723799 XM_006723800

HUGO

HGNC:8155

OMIM

602548

CCDS

CCDS13556

HPRD

IMGT

EMBL

AF126470 AF348323 AL121581 AL590548 AY268428 BC038433 CR542061 L40949 U30185 X77130

GenPept

AAA84913 AAA96251 AAH38433 AAK11714 AAL54890 AAP23195 CAA54386 CAC17003 CAD11904 CAG46858

RNA Seq Atlas

4987