InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2I

Summary

InnateDB Gene

IDBG-8784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2I

Gene Name

ubiquitin-conjugating enzyme E2I

Synonyms

C358B7.1; P18; UBC9

Species

Homo sapiens

Ensembl Gene

ENSG00000103275

Encoded Proteins

IDBP-8786

ubiquitin-conjugating enzyme E2I

IDBP-8788

ubiquitin-conjugating enzyme E2I

IDBP-235200

ubiquitin-conjugating enzyme E2I

IDBP-235202

ubiquitin-conjugating enzyme E2I

IDBP-292682

ubiquitin-conjugating enzyme E2I

IDBP-292681

ubiquitin-conjugating enzyme E2I

IDBP-292680

ubiquitin-conjugating enzyme E2I

IDBP-751874

IDBP-751918

IDBP-749445

IDBP-750591

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26348439

[Mus musculus] Baiap2l1 recruits Ube2i to sumoylate Pcbp2, which causes its cytoplasmic translocation during viral infection and the sumoylated Pcbp2 associates with Mavs to initiate its degradation, leading to downregulation of antiviral responses.

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1308880-1327018

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000339021
ENST00000325437	ENSP00000324897
ENST00000355803	ENSP00000348056
ENST00000397515	ENSP00000380650
ENST00000397514	ENSP00000380649
ENST00000406620	ENSP00000384568
ENST00000403747	ENSP00000385009
ENST00000402301	ENSP00000384361
ENST00000473256
ENST00000566587	ENSP00000457064
ENST00000567383	ENSP00000456188
ENST00000568288
ENST00000568989
ENST00000564143
ENST00000562482
ENST00000566159
ENST00000562470
ENST00000566775	ENSP00000455252
ENST00000568209
ENST00000567074	ENSP00000455893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 382 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	382 [view]
Protein-Protein	380 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0043398	HLH domain binding
GO:0043425	bHLH transcription factor binding
GO:0044822	poly(A) RNA binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0010469	regulation of receptor activity
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0016925	protein sumoylation
GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0000795	synaptonemal complex
GO:0001650	fibrillar center
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0030425	dendrite
GO:0045202	synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015120

View Gene Order

ENSBTAG00000038866

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_9

TNFalpha pathway

REACTOME

REACT_75792

Meiotic synapsis pathway

REACT_22161

Post-translational protein modification pathway

REACT_163793

Processing and activation of SUMO pathway

REACT_115566

Cell Cycle pathway

REACT_17015

Metabolism of proteins pathway

REACT_163646

SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway

REACT_163823

SUMOylation pathway

REACT_111183

Meiosis pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa03013

RNA transport pathway

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

hdac_classi_pathway

Signaling events mediated by HDAC Class I

hdac_classii_pathway

Signaling events mediated by HDAC Class II

cmyb_pathway

C-MYB transcription factor network

ranbp2pathway

Sumoylation by RanBP2 regulates transcriptional repression

smad2_3pathway

Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Cross-References

SwissProt

P63279

TrEMBL

H3BQQ9 H3BRD1

UniProt Splice Variant

Entrez Gene

7329

UniGene

Hs.302903 Hs.601609 Hs.673607 Hs.684741

RefSeq

NM_003345 NM_194259 NM_194260 NM_194261 XM_005255540 XM_005255541 XM_006720938 XM_006720939

HUGO

HGNC:12485

OMIM

601661

CCDS

CCDS10433

HPRD

09045

IMGT

EMBL

AB208988 AC120498 AE006466 AJ002385 AL031714 BC000427 BC004429 BC051289 BT006932 CH471112 D45050 U29092 U31882 U31933 U38785 U45328 U66818 U66867 X96427

GenPept

AAA86662 AAB02181 AAB09410 AAC50603 AAC50715 AAC50716 AAC51361 AAH00427 AAH04429 AAH51289 AAK61274 AAP35578 BAA08091 BAD92225 CAA05359 CAA65287 CAB45853 EAW85673 EAW85676 EAW85677 EAW85678 EAW85679

RNA Seq Atlas

7329