Homo sapiens Gene: NFKB2
Summary
InnateDB Gene IDBG-87893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKB2
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Synonyms CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100; p52;
Species Homo sapiens
Ensembl Gene ENSG00000077150
Encoded Proteins
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NFKB2 (p49/p100 subunit) associates efficiently with RELB and up-regulates the synthesis of NFKBIA (IKappaB-alpha).
NFKB2 plays a key role in the regulation of RELA activation, suggesting an overlap in the function of NF-kappaB members in canonical and non-canonical pathway signalling.
NFKB2 rearrangement gene product (p58) localizes in the nucleus to form a complex with RELA or RELB, suggesting that such NFKB2 gene rearrangement may therefore be a factor in the constitutive activation of NF-kappaB in adult T-cell leukemia (ATL), and thereby playing a role in the ATL pathogenesis.
NFKB2 negatively regulates TCR signaling by binding with RELA, RELB, REL and NFKB1 (p50) in the cytoplasm and inhibiting these proteins from entering nucleus.
NFKB2 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.
Entrez Gene
Summary This gene encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. This gene encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor, depending on its dimer partner. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, May 2012]
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:102394110-102402529
Strand Forward strand
Band q24.32
Transcripts
ENST00000336486
ENST00000369966 ENSP00000358983
ENST00000189444 ENSP00000189444
ENST00000428099 ENSP00000410256
ENST00000471698 ENSP00000471586
ENST00000467116
ENST00000473400
ENST00000601386 ENSP00000470826
ENST00000593908
ENST00000610498 ENSP00000480211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 89 [view]
Protein-DNA 33 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002268 follicular dendritic cell differentiation
GO:0002467 germinal center formation
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0030198 extracellular matrix organization
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048536 spleen development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033257 Bcl3/NF-kappaB2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
RANKL pathway
TSLP pathway
TWEAK pathway
REACTOME
RIP-mediated NFkB activation via ZBP1 pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interleukin-1 processing pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
MAPK signaling pathway pathway
Osteoclast differentiation pathway
Pathways in cancer pathway
INOH
PID BIOCARTA
PID NCI
IL12-mediated signaling events
Alternative NF-kappaB pathway
Cross-References
SwissProt
TrEMBL M0QZX1 M0R119
UniProt Splice Variant
Entrez Gene 4791
UniGene Hs.73090 Hs.742532
RefSeq NM_001077494 NM_001261403 NM_002502 NM_001288724 XM_005269861 XM_005269860
HUGO HGNC:7795
OMIM 164012
CCDS CCDS41564 CCDS41565
HPRD 01239
IMGT
EMBL AL121928
GenPept
RNA Seq Atlas 4791