InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPTAN1

Summary

InnateDB Gene

IDBG-88280.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTAN1

Gene Name

spectrin, alpha, non-erythrocytic 1

Synonyms

EIEE5; NEAS; SPTA2

Species

Homo sapiens

Ensembl Gene

ENSG00000197694

Encoded Proteins

IDBP-88282

spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

IDBP-88284

spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

IDBP-88288

spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:128552558-128633665

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000372739	ENSP00000361824
ENST00000372731	ENSP00000361816
ENST00000358161	ENSP00000350882
ENST00000497216
ENST00000472211
ENST00000475367
ENST00000461855
ENST00000476825
ENST00000491712

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	147 [view]
Protein-Protein	146 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030507	spectrin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007411	axon guidance
GO:0051693	actin filament capping

Cellular Component

GO:0005829	cytosol
GO:0005916	fascia adherens
GO:0008091	spectrin
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0032437	cuticular plate
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome