Homo sapiens Gene: ERRFI1
Summary
InnateDB Gene IDBG-88341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERRFI1
Gene Name ERBB receptor feedback inhibitor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116285
Encoded Proteins
ERBB receptor feedback inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:8004404-8026308
Strand Reverse strand
Band p36.23
Transcripts
ENST00000377482 ENSP00000366702
ENST00000474874 ENSP00000466958
ENST00000467067 ENSP00000465100
ENST00000469499 ENSP00000466454
ENST00000487559 ENSP00000467030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
Biological Process
GO:0006950 response to stress
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0031953 negative regulation of protein autophosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043589 skin morphogenesis
GO:0045616 regulation of keratinocyte differentiation
GO:0048286 lung alveolus development
GO:0060426 lung vasculature development
GO:0060428 lung epithelium development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UJM3
TrEMBL I6S2Y9
UniProt Splice Variant
Entrez Gene 54206
UniGene Hs.605445
RefSeq NM_018948 XM_005263477 XM_006710697
HUGO HGNC:18185
OMIM 608069
CCDS CCDS94
HPRD 09218
IMGT
EMBL AJ276373 AK315718 AL034417 AL137274 BC025337 CH471130 JQ867454
GenPept AAH25337 AFM52327 BAG38076 CAB52551 CAB70672 CAC20426 EAW71593 EAW71594
RNA Seq Atlas 54206