Version 5.4
Homo sapiens Gene: ERRFI1
Summary
InnateDB Gene IDBG-88341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERRFI1
Gene Name ERBB receptor feedback inhibitor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116285
Encoded Proteins
IDBP-88343
ERBB receptor feedback inhibitor 1
IDBP-722516
IDBP-721779
IDBP-721973
IDBP-721855
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:8004404-8026308
Strand Reverse strand
Band p36.23
Transcripts
ENST00000377482 ENSP00000366702
ENST00000474874 ENSP00000466958
ENST00000467067 ENSP00000465100
ENST00000469499 ENSP00000466454
ENST00000487559 ENSP00000467030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
Biological Process
GO:0006950 response to stress
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0031953 negative regulation of protein autophosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043589 skin morphogenesis
GO:0045616 regulation of keratinocyte differentiation
GO:0048286 lung alveolus development
GO:0060426 lung vasculature development
GO:0060428 lung epithelium development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028967
View Gene Order
ENSBTAG00000006609
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.605445
RefSeq NM_018948 XM_005263477 XM_006710697
HUGO
OMIM
CCDS CCDS94
HPRD 09218
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca