Homo sapiens Gene: TAF5
Summary
InnateDB Gene IDBG-88423.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF5
Gene Name TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Synonyms TAF2D; TAFII100;
Species Homo sapiens
Ensembl Gene ENSG00000148835
Encoded Proteins
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:103367967-103389065
Strand Forward strand
Band q24.33
Transcripts
ENST00000369839 ENSP00000358854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
GO:0016568 chromatin modification
GO:0016573 histone acetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0015629 actin cytoskeleton
GO:0033276 transcription factor TFTC complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation pathway
Late Phase of HIV Life Cycle pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
RNA Polymerase II Pre-transcription Events pathway
Transcription of the HIV genome pathway
HIV Infection pathway
HIV Transcription Initiation pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
KEGG
Basal transcription factors pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15542
TrEMBL
UniProt Splice Variant
Entrez Gene 6877
UniGene Hs.96103
RefSeq NM_006951
HUGO HGNC:11539
OMIM 601787
CCDS CCDS7547
HPRD
IMGT
EMBL AK223615 AK291229 AL591408 BC052268 BC136340 BC136348 CH471066 U75309 U80191 X95525
GenPept AAC50902 AAC51215 AAH52268 AAI36341 AAI36349 BAD97335 BAF83918 CAA64777 CAI16747 EAW49645 EAW49646
RNA Seq Atlas 6877