Homo sapiens Gene: CRAT
Summary
InnateDB Gene IDBG-88989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRAT
Gene Name carnitine O-acetyltransferase
Synonyms CAT1;
Species Homo sapiens
Ensembl Gene ENSG00000095321
Encoded Proteins
carnitine O-acetyltransferase
carnitine O-acetyltransferase
carnitine O-acetyltransferase
carnitine O-acetyltransferase
carnitine O-acetyltransferase
carnitine O-acetyltransferase
carnitine O-acetyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:129094810-129111189
Strand Reverse strand
Band q34.11
Transcripts
ENST00000318080 ENSP00000315013
ENST00000393384 ENSP00000377045
ENST00000455396 ENSP00000395458
ENST00000458362 ENSP00000400367
ENST00000415948 ENSP00000394420
ENST00000441796 ENSP00000404405
ENST00000455830 ENSP00000390571
ENST00000467343
ENST00000464290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004092 carnitine O-acetyltransferase activity
GO:0005102 receptor binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006810 transport
GO:0008152 metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005783 endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta-oxidation of pristanoyl-CoA pathway
Peroxisomal lipid metabolism pathway
Beta-oxidation of very long chain fatty acids pathway
Metabolism pathway
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B7ZBP5
UniProt Splice Variant
Entrez Gene 1384
UniGene Hs.623219
RefSeq NM_000755 NM_001257363 XM_005251709 XM_005251707
HUGO HGNC:2342
OMIM 600184
CCDS CCDS6919
HPRD 08971
IMGT
EMBL AL158151
GenPept
RNA Seq Atlas 1384