Version 5.4
Homo sapiens Gene: CRAT
Summary
InnateDB Gene IDBG-88989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRAT
Gene Name carnitine O-acetyltransferase
Synonyms CAT1
Species Homo sapiens
Ensembl Gene ENSG00000095321
Encoded Proteins
IDBP-88993
carnitine O-acetyltransferase
IDBP-243720
carnitine O-acetyltransferase
IDBP-382095
carnitine O-acetyltransferase
IDBP-382098
carnitine O-acetyltransferase
IDBP-382099
carnitine O-acetyltransferase
IDBP-382100
carnitine O-acetyltransferase
IDBP-382104
carnitine O-acetyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:129094810-129111189
Strand Reverse strand
Band q34.11
Transcripts
ENST00000318080 ENSP00000315013
ENST00000393384 ENSP00000377045
ENST00000455396 ENSP00000395458
ENST00000458362 ENSP00000400367
ENST00000415948 ENSP00000394420
ENST00000441796 ENSP00000404405
ENST00000455830 ENSP00000390571
ENST00000467343
ENST00000464290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004092 carnitine O-acetyltransferase activity
GO:0005102 receptor binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006810 transport
GO:0008152 metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005783 endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026853
View Gene Order
ENSBTAG00000001932
Not yet available
Pathways
NETPATH
REACTOME
REACT_17062
Beta-oxidation of very long chain fatty acids pathway
REACT_17017
Beta-oxidation of pristanoyl-CoA pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623219
RefSeq NM_000755 NM_001257363 XM_005251707 XM_005251709
HUGO
OMIM
CCDS CCDS6919
HPRD 08971
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca