Homo sapiens Gene: PGD
Summary
InnateDB Gene IDBG-89009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGD
Gene Name phosphogluconate dehydrogenase
Synonyms 6PGD;
Species Homo sapiens
Ensembl Gene ENSG00000142657
Encoded Proteins
phosphogluconate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10398592-10420144
Strand Forward strand
Band p36.22
Transcripts
ENST00000270776 ENSP00000270776
ENST00000491493 ENSP00000466358
ENST00000487775
ENST00000477958 ENSP00000465311
ENST00000483936 ENSP00000466156
ENST00000465632 ENSP00000466574
ENST00000460189 ENSP00000467362
ENST00000493288
ENST00000498356
ENST00000496718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0050661 NADP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0019322 pentose biosynthetic process
GO:0019521 D-gluconate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pentose phosphate pathway (hexose monophosphate shunt) pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Pentose phosphate pathway pathway
Glutathione metabolism pathway
INOH
Pentose phosphate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5226
UniGene Hs.464071 Hs.592867
RefSeq NM_002631
HUGO HGNC:8891
OMIM 172200
CCDS CCDS113
HPRD 01391
IMGT
EMBL
GenPept
RNA Seq Atlas 5226