Version 5.4
Homo sapiens Gene: PGD
Summary
InnateDB Gene IDBG-89009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGD
Gene Name phosphogluconate dehydrogenase
Synonyms 6PGD
Species Homo sapiens
Ensembl Gene ENSG00000142657
Encoded Proteins
IDBP-89011
phosphogluconate dehydrogenase
IDBP-721814
IDBP-722108
IDBP-722136
IDBP-721699
IDBP-722381
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10398592-10420144
Strand Forward strand
Band p36.22
Transcripts
ENST00000270776 ENSP00000270776
ENST00000491493 ENSP00000466358
ENST00000487775
ENST00000477958 ENSP00000465311
ENST00000483936 ENSP00000466156
ENST00000465632 ENSP00000466574
ENST00000460189 ENSP00000467362
ENST00000493288
ENST00000498356
ENST00000496718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0050661 NADP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0019322 pentose biosynthetic process
GO:0019521 D-gluconate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028961
View Gene Order
ENSBTAG00000013527
Not yet available
Pathways
NETPATH
REACTOME
REACT_1859
Pentose phosphate pathway (hexose monophosphate shunt) pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00030
Pentose phosphate pathway pathway
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.464071 Hs.592867
RefSeq NM_002631
HUGO
OMIM
CCDS CCDS113
HPRD 01391
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca