Homo sapiens Gene: TARDBP
Summary
InnateDB Gene IDBG-89123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARDBP
Gene Name TAR DNA binding protein
Synonyms ALS10; TDP-43;
Species Homo sapiens
Ensembl Gene ENSG00000120948
Encoded Proteins
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
TAR DNA binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11012344-11026420
Strand Forward strand
Band p36.22
Transcripts
ENST00000240185 ENSP00000240185
ENST00000315091 ENSP00000313129
ENST00000439080 ENSP00000404666
ENST00000473118 ENSP00000465240
ENST00000476201 ENSP00000466842
ENST00000472476 ENSP00000465080
ENST00000473869 ENSP00000432132
ENST00000477447 ENSP00000465888
ENST00000496840 ENSP00000467020
ENST00000480464
ENST00000613864
ENST00000621715 ENSP00000480690
ENST00000621790 ENSP00000482191
ENST00000616545 ENSP00000484722
ENST00000622057 ENSP00000481206
ENST00000617172 ENSP00000479219
ENST00000618606
ENST00000611963 ENSP00000481330
ENST00000620632 ENSP00000480771
ENST00000619555 ENSP00000479978
ENST00000610369 ENSP00000482559
ENST00000614494 ENSP00000482754
ENST00000620505 ENSP00000479758
ENST00000621573 ENSP00000477852
ENST00000611008
ENST00000613177
ENST00000617757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 311 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 311 [view]
Protein-Protein 311 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008219 cell death
GO:0008380 RNA splicing
GO:0043922 negative regulation by host of viral transcription
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070935 3'-UTR-mediated mRNA stabilization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.300624 Hs.638997 Hs.640648 Hs.731614
RefSeq NM_007375
HUGO
OMIM
CCDS CCDS122
HPRD 05466
IMGT
EMBL
GenPept
RNA Seq Atlas