Homo sapiens Gene: MTOR
Summary
InnateDB Gene IDBG-89258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTOR
Gene Name mechanistic target of rapamycin (serine/threonine kinase)
Synonyms FRAP; FRAP1; FRAP2; RAFT1; RAPT1;
Species Homo sapiens
Ensembl Gene ENSG00000198793
Encoded Proteins
mechanistic target of rapamycin (serine/threonine kinase)
mechanistic target of rapamycin (serine/threonine kinase)
mechanistic target of rapamycin (serine/threonine kinase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MTOR is the signalling molecule involved in TLR-mediated IFN-alpha production by plasmacytoid dendritic cells (pDCs).
MTOR is an indispensable component of pathogen recognition receptor (PRR) signal pathways that orchestrates the defence program of innate immune cells.
MTOR plays a central role in cell growth and cellular responses to metabolic stress and its activation is essential in TLR2- and TLR4-induced neutrophil activation, as well as in the development and severity of acute lung injury.
MTOR signalling is one major mechanism in a tightly regulated network of intracellular signal pathways including the JAK/STAT system to regulate invasion in human trophoblast cells by secretion of enzymes that remodel the extra-cellular matrix (ECM) such as MMP2, MMP9, PLAU and SERPINE1.
Inhibition of mTOR blocks the anti-inflammatory potency of glucocorticoids both in human monocytes and myeloid dendritic cells.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Inhibition of mTOR blocks the anti-inflammatory potency of glucocorticoids both in human monocytes and myeloid dendritic cells. (Demonstrated in human)
[Mus musculus] The interplay between Tsc1-Rheb-mTOR complex 1 signalling and Myc-dependent metabolism are dynamically regulated during dentritic cell (DC) development, whereas uncontrolled mTORC1 activation impairs DC development.
Entrez Gene
Summary The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11106535-11262507
Strand Reverse strand
Band p36.22
Transcripts
ENST00000376838 ENSP00000366034
ENST00000361445 ENSP00000354558
ENST00000455339 ENSP00000398745
ENST00000473471
ENST00000490931
ENST00000495435
ENST00000476768
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 230 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 230 [view]
Protein-Protein 226 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
GO:0001156 TFIIIC-class transcription factor binding
GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019904 protein domain specific binding
GO:0043022 ribosome binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005979 regulation of glycogen biosynthetic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007281 germ cell development
GO:0007584 response to nutrient
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010507 negative regulation of autophagy
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010831 positive regulation of myotube differentiation
GO:0016049 cell growth
GO:0016242 negative regulation of macroautophagy
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030030 cell projection organization
GO:0030163 protein catabolic process
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031529 ruffle organization
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032095 regulation of response to food
GO:0032314 regulation of Rac GTPase activity
GO:0032868 response to insulin
GO:0032956 regulation of actin cytoskeleton organization
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0040007 growth
GO:0043200 response to amino acid
GO:0043610 regulation of carbohydrate utilization
GO:0045087 innate immune response (InnateDB)
GO:0045727 positive regulation of translation
GO:0045792 negative regulation of cell size
GO:0045859 regulation of protein kinase activity
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051496 positive regulation of stress fiber assembly
GO:0051534 negative regulation of NFAT protein import into nucleus
GO:0051897 positive regulation of protein kinase B signaling
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016605 PML body
GO:0030425 dendrite
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
GO:0043025 neuronal cell body
GO:0070438 mTOR-FKBP12-rapamycin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
IL2 pathway
RANKL pathway
Leptin pathway
TSH pathway
FSH pathway
Prolactin pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PKB-mediated events pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
mTOR signalling pathway
Release of eIF4E pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
mTORC1-mediated signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
CD28 co-stimulation pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
S6K1-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
HSF1-dependent transactivation pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
Cellular response to heat stress pathway
IRS-related events pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
mTOR signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Pathways in cancer pathway
Glioma pathway
Prostate cancer pathway
Acute myeloid leukemia pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Ctcf: first multivalent nuclear factor [Biocarta view]
B cell survival pathway [Biocarta view]
Regulation of eif-4e and p70s6 kinase [Biocarta view]
Stat3 signaling pathway [Biocarta view]
Mtor signaling pathway [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events mediated by Akt
CXCR4-mediated signaling events
IL12-mediated signaling events
ErbB1 downstream signaling
mTOR signaling pathway
LKB1 signaling events
EGFR-dependent Endothelin signaling events
IL4-mediated signaling events
ErbB2/ErbB3 signaling events
CDC42 signaling events
CXCR3-mediated signaling events
IL2 signaling events mediated by PI3K
Regulation of Telomerase
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.338207 Hs.659634
RefSeq NM_004958 XM_005263438 XM_005263439
HUGO
OMIM
CCDS CCDS127
HPRD 03134
IMGT
EMBL
GenPept
RNA Seq Atlas