Homo sapiens Gene: ABL1
Summary
InnateDB Gene IDBG-89599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABL1
Gene Name c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms ABL; bcr/abl; c-ABL; c-ABL1; JTK7; p150; v-abl;
Species Homo sapiens
Ensembl Gene ENSG00000097007
Encoded Proteins
c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, non-receptor tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ABL1 kinase is required for neutrophil migration.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] ABL1 kinase is required for neutrophil migration.
Entrez Gene
Summary The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5\' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:130713946-130887675
Strand Forward strand
Band q34.12
Transcripts
ENST00000372348 ENSP00000361423
ENST00000318560 ENSP00000323315
ENST00000393293 ENSP00000376971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 266 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 266 [view]
Protein-Protein 264 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003785 actin monomer binding
GO:0004515 nicotinate-nucleotide adenylyltransferase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
GO:0019905 syntaxin binding
GO:0030145 manganese ion binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0006298 mismatch repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010506 regulation of autophagy
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030100 regulation of endocytosis
GO:0030155 regulation of cell adhesion
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042692 muscle cell differentiation
GO:0042770 signal transduction in response to DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051353 positive regulation of oxidoreductase activity
GO:0051726 regulation of cell cycle
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001020 regulation of response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0031252 cell leading edge
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TCR pathway
RANKL pathway
FSH pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
CDO in myogenesis pathway
Innate Immune System pathway
Axon guidance pathway
Myogenesis pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Factors involved in megakaryocyte development and platelet production pathway
Signaling by Robo receptor pathway
Role of Abl in Robo-Slit signaling pathway
Hemostasis pathway
KEGG
ErbB signaling pathway pathway
Cell cycle pathway
Axon guidance pathway
Neurotrophin signaling pathway pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
Atm signaling pathway [Biocarta view]
Cell cycle: g1/s check point [Biocarta view]
Lissencephaly gene (lis1) in neuronal migration and development [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
p53 pathway
Neurotrophic factor-mediated Trk receptor signaling
p73 transcription factor network
ATM pathway
Validated transcriptional targets of TAp63 isoforms
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.431048
RefSeq NM_005157 NM_007313
HUGO
OMIM
CCDS CCDS35165 CCDS35166
HPRD 01809
IMGT
EMBL
GenPept
RNA Seq Atlas