Homo sapiens Gene: RBX1
InnateDB Gene IDBG-8962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBX1
Gene Name ring-box 1, E3 ubiquitin protein ligase
Synonyms BA554C12.1; RNF75; ROC1
Species Homo sapiens
Ensembl Gene ENSG00000100387
Encoded Proteins
ring-box 1, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:40951347-40973309
Strand Forward strand
Band q13.2
ENST00000216225 ENSP00000216225
Number of Interactions This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 213 [view]
Protein-Protein 213 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019788 NEDD8 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0007219 Notch signaling pathway
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045116 protein neddylation
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0030891 VCB complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
GO:0031467 Cul7-RING ubiquitin ligase complex
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Notch pathway
TGF_beta_Receptor pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Interleukin-1 signaling pathway
Prolactin receptor signaling pathway
Nuclear signaling by ERBB4 pathway
Signaling by ERBB4 pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Degradation of beta-catenin by the destruction complex pathway
Vif-mediated degradation of APOBEC3G pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
truncated APC mutants destabilize the destruction complex pathway
Cellular responses to stress pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
Cytokine Signaling in Immune system pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Immune System pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Cellular response to hypoxia pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
Renal cell carcinoma pathway
Ubiquitin mediated proteolysis pathway
Circadian rhythm pathway
Nucleotide excision repair pathway
Pathways in cancer pathway
Oocyte meiosis pathway
Protein processing in endoplasmic reticulum pathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
SwissProt P62877
UniProt Splice Variant
Entrez Gene 9978
RefSeq NM_014248
OMIM 603814
EMBL AF140598 AF142059 AK315722 AL080242 AY099360 BC001466 BC017370 CH471095 CR456560
GenPept AAD29715 AAD30146 AAH01466 AAH17370 AAM21718 BAG38078 CAB62925 CAG30446 EAW60403
RNA Seq Atlas 9978