Version 5.4
Homo sapiens Gene: TCF7L2
Summary
InnateDB Gene IDBG-89861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF7L2
Gene Name transcription factor 7-like 2 (T-cell specific, HMG-box)
Synonyms TCF-4; TCF4
Species Homo sapiens
Ensembl Gene ENSG00000148737
Encoded Proteins
IDBP-89863
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89865
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89867
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89869
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89871
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89873
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89875
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89881
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89883
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-89885
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-602164
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-597707
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-589422
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-602910
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-590546
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-600852
transcription factor 7-like 2 (T-cell specific, HMG-box)
IDBP-598115
transcription factor 7-like 2 (T-cell specific, HMG-box)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:112950250-113167678
Strand Forward strand
Band q25.2
Transcripts
ENST00000369397 ENSP00000358404
ENST00000349937 ENSP00000298692
ENST00000352065 ENSP00000344823
ENST00000355995 ENSP00000348274
ENST00000355717 ENSP00000347949
ENST00000277945 ENSP00000277945
ENST00000369395 ENSP00000358402
ENST00000346198 ENSP00000345640
ENST00000369389 ENSP00000358396
ENST00000369386 ENSP00000358393
ENST00000466338
ENST00000470254 ENSP00000435694
ENST00000480888
ENST00000471569
ENST00000476887
ENST00000494353
ENST00000545257 ENSP00000440547
ENST00000543371 ENSP00000444972
ENST00000536810 ENSP00000446238
ENST00000538897 ENSP00000446172
ENST00000534894 ENSP00000443626
ENST00000542695 ENSP00000443883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 44 [view]
Protein-DNA 7 [view]
Protein-RNA 1 [view]
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0035257 nuclear hormone receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0005977 glycogen metabolic process
GO:0006006 glucose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007050 cell cycle arrest
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 oligodendrocyte development
GO:0016055 Wnt signaling pathway
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030282 bone mineralization
GO:0030514 negative regulation of BMP signaling pathway
GO:0030538 embryonic genitalia morphogenesis
GO:0031016 pancreas development
GO:0031641 regulation of myelination
GO:0032024 positive regulation of insulin secretion
GO:0032092 positive regulation of protein binding
GO:0032252 secretory granule localization
GO:0032350 regulation of hormone metabolic process
GO:0035019 somatic stem cell maintenance
GO:0035264 multicellular organism growth
GO:0035411 catenin import into nucleus
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043570 maintenance of DNA repeat elements
GO:0043588 skin development
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046621 negative regulation of organ growth
GO:0046827 positive regulation of protein export from nucleus
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048557 embryonic digestive tract morphogenesis
GO:0048619 embryonic hindgut morphogenesis
GO:0048625 myoblast fate commitment
GO:0048641 regulation of skeletal muscle tissue development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048699 generation of neurons
GO:0048713 regulation of oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901142 insulin metabolic process
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0032993 protein-DNA complex
GO:0070369 beta-catenin-TCF7L2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024985
View Gene Order
ENSBTAG00000021574
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
NetPath_8
Wnt pathway
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_200799
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_172761
Ca2+ pathway pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_17015
Metabolism of proteins pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05216
Thyroid cancer pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa05215
Prostate cancer pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt Q9NQB0
TrEMBL C6ZRJ7
UniProt Splice Variant
Entrez Gene 6934
UniGene Hs.613812 Hs.706243
RefSeq NM_001198525 NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756 XM_005270080 XM_005270082 XM_005270083 XM_005270084 XM_005270085 XM_005270086 XM_005270088 XM_005270089 XM_005270096 XM_006717955 XM_006717956 XM_006717957 XM_006717958
HUGO HGNC:11641
OMIM 602228
CCDS CCDS73196 CCDS53578 CCDS55729 CCDS73197 CCDS73198 CCDS7576
HPRD 03751
IMGT
EMBL AB034691 AB440195 AJ270770 AJ270771 AJ270772 AJ270773 AJ270774 AJ270775 AJ270776 AJ270777 AJ270778 AK299295 AL135792 AL158212 AL445486 AL451084 BC032656 CH471066 FJ010166 FJ010167 FJ010169 FJ010172 HM352839 HM352842 HM352844 HM352845 HM352846 HM352847 HM352849 HM352850 Y11306
GenPept AAH32656 ACI28524 ACI28525 ACI28527 ACI28530 ADK35175 ADK35178 ADK35180 ADK35181 ADK35182 ADK35184 ADK35185 ADK35187 BAA86225 BAG61310 BAH24004 CAA72166 CAB97212 CAB97213 CAB97214 CAB97215 CAB97216 CAB97217 CAB97218 CAB97219 EAW49513 EAW49515 EAW49516
RNA Seq Atlas 6934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca